DegronMD - Q01629(IFITM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P17L	TCGA-55-6985	LUAD	TCGA	PPNY	ITCH	16:19	Mutation altering degron motif	0.7582
p.P17L	DO25659	LUAD	ICGC	PPNY	ITCH	16:19	Mutation altering degron motif	0.7582
p.F8L	TCGA-AG-A002	READ	TCGA	PPNY	ITCH	16:19	Mutation rewiring degron network	0.1111
p.M21I	TCGA-AX-A1CE	UCEC	TCGA	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.E20K	TCGA-FS-A1ZZ	SKCM	TCGA	PPNY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.E20K	DO234437	ESAD	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.E20K	DO37412	SKCM	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.V24A	DO4683	BRCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.1944
p.M21T	DO229010	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.M21T	DO229013	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.M21T	DO229016	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.M21T	DO229003	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.M21T	DO229005	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.M21T	DO221075	WT	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.V13A	DO229010	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13A	DO229013	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13A	DO229016	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13A	DO229003	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13A	DO229005	COCA	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13A	DO234285	ESAD	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.25
p.P19S	DO13863	GBM	ICGC	PPNY	ITCH	16:19	Mutation altering degron motif	0.6752
p.G22R	DO44459	KIRC	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.25
p.H15N	DO27421	LUSC	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.P17S	DO220886	MELA	ICGC	PPNY	ITCH	16:19	Mutation altering degron motif	0.6752
p.R14K	DO38404	STAD	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.A18S	DO47827	STAD	ICGC	PPNY	ITCH	16:19	Mutation altering degron motif	0.7588
p.D19N	DO47717	STAD	ICGC	PPNY	ITCH	16:19	Mutation altering degron motif	0.6932
p.R28C	DO52402	UCEC	ICGC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.0833
p.G14D	SIDM00238	Ovarian Carcinoma	GDSC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.G14D	ACH-000947	Ovarian Cancer	CCLE	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.G14D	OVK-18	ovary	COSMIC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.Q26H	SIDM00849	Kidney Carcinoma	GDSC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.1389
p.Q26H	A704	kidney	COSMIC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.1389
p.Q6H	A704	kidney	COSMIC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.0556
p.S29N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	16:19	Mutation rewiring degron network	0.0556

Kaplan plot for IFITM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFITM2

UniProt ID: Q01629

Entrez ID: 10581

Protein name: Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IFITM2 in