DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
CDR2
UniProt ID:
Q01850
Entrez ID:
1039
Protein name:
Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
cytoplasm [GO:0005737]...
cytoplasm [GO:0005737]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
CDR2
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ICGC
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CCLE
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Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.I429V
TCGA-A5-A0VQ
UCEC
TCGA
PPEY
ITCH
419:422
Mutation rewiring degron network
0.1389
p.I429V
DO42113
UCEC
ICGC
PPEY
ITCH
419:422
Mutation rewiring degron network
0.1389
p.P419L
TCGA-B5-A3FA
UCEC
TCGA
PPEY
ITCH
419:422
Mutation altering degron motif
0.7582
p.P419L
DO52402
UCEC
ICGC
PPEY
ITCH
419:422
Mutation altering degron motif
0.7582
p.P412S
TCGA-BF-A3DJ
SKCM
TCGA
PPEY
ITCH
419:422
Mutation rewiring degron network
0.1389
p.P412S
DO51237
SKCM
ICGC
PPEY
ITCH
419:422
Mutation rewiring degron network
0.1389
p.P416H
TCGA-FI-A2D5
UCEC
TCGA
PPEY
ITCH
419:422
Mutation rewiring degron network
0.25
p.P416H
DO41331
UCEC
ICGC
PPEY
ITCH
419:422
Mutation rewiring degron network
0.25
p.A424E
DO229019
LICA
ICGC
PPEY
ITCH
419:422
Mutation rewiring degron network
0.2778
p.N409K
DO229028
LICA
ICGC
PPEY
ITCH
419:422
Mutation rewiring degron network
0.0556
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for CDR2 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc