DegronMD - Q01892(SPIB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P117L	TCGA-18-3409	LUSC	TCGA	PPAY	ITCH	117:120	Mutation altering degron motif	0.7582
p.P117L	DO26444	LUSC	ICGC	PPAY	ITCH	117:120	Mutation altering degron motif	0.7582
p.E79K	TCGA-2W-A8YY	CESC	TCGA	PPTY	ITCH	80:83	Mutation rewiring degron network	0.3056
p.E79K	TCGA-AA-3510	COAD	TCGA	PPTY	ITCH	80:83	Mutation rewiring degron network	0.3056
p.E79K	DO223732	CESC	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.3056
p.E79K	DO7783	COAD	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.3056
p.E79K	DO228647	PRAD	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.3056
p.E130Q	TCGA-46-6026	LUSC	TCGA	PPAY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.G87W	TCGA-A6-5665	COAD	TCGA	PPTY	ITCH	80:83	Mutation rewiring degron network	0.2222
p.G87W	DO9756	COAD	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.2222
p.A119T	TCGA-BP-5177	KIRC	TCGA	PPAY	ITCH	117:120	Mutation altering degron motif	0.6028
p.Y83C	TCGA-BR-4201	STAD	TCGA	PPTY	ITCH	80:83	Mutation altering degron motif	0.7087
p.Y83C	DO38707	STAD	ICGC	PPTY	ITCH	80:83	Mutation altering degron motif	0.7087
p.Y83C	SIDM01045	Endometrial Carcinoma	GDSC	PPTY	ITCH	80:83	Mutation altering degron motif	0.7087
p.Y83C	EN	endometrium	COSMIC	PPTY	ITCH	80:83	Mutation altering degron motif	0.7087
p.Y83N	TCGA-BR-8690	STAD	TCGA	PPTY	ITCH	80:83	Mutation altering degron motif	0.7059
p.Y83N	DO47911	STAD	ICGC	PPTY	ITCH	80:83	Mutation altering degron motif	0.7059
p.P118S	TCGA-D6-6516	HNSC	TCGA	PPAY	ITCH	117:120	Mutation altering degron motif	0.6752
p.T107M	TCGA-E6-A1LX	UCEC	TCGA	PPAY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.T107M	DO41020	UCEC	ICGC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.G87E	TCGA-EE-A2MR	SKCM	TCGA	PPTY	ITCH	80:83	Mutation rewiring degron network	0.2222
p.G87E	DO37819	SKCM	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.2222
p.V116A	TCGA-EO-A3B0	UCEC	TCGA	PPAY	ITCH	117:120	Mutation rewiring degron network	0.3056
p.V116A	DO219773	UCEC	ICGC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.3056
p.E90K	TCGA-FW-A3R5	SKCM	TCGA	PPTY	ITCH	80:83	Mutation rewiring degron network	0.1389
p.E90K	DO37406	SKCM	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.1389
p.G77R	DO49895	CESC	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.25
p.G77R	DO25464	LUAD	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.25
p.G77R	DO43891	UCEC	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.25
p.R128L	DO8938	COAD	ICGC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.1111
p.R130H	DO8490	COAD	ICGC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.R130C	DO228602	GACA	ICGC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.N88S	DO233693	GACA	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.1944
p.P81H	DO233709	GACA	ICGC	PPTY	ITCH	80:83	Mutation altering degron motif	0.7694
p.L72F	DO49418	PACA	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.1111
p.G73R	DO35442	PACA	ICGC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.1389
p.G73R	EW-13	bone	COSMIC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.1389
p.V127G	SIDM00796	Head and Neck Carcinoma	GDSC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.1389
p.P126L	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.1667
p.P126L	HAL-01	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	117:120	Mutation rewiring degron network	0.1667
p.A86T	SIDM01619	Endometrial Carcinoma	GDSC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.25
p.E71K	HDQ-P1	breast	COSMIC	PPTY	ITCH	80:83	Mutation rewiring degron network	0.0833

Kaplan plot for SPIB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPIB

UniProt ID: Q01892

Entrez ID: 6689

Protein name: Transcription factor Spi-B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPIB in