DegronMD - Q02410(APBA1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L419V	TCGA-39-5031	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.L419V	TCGA-BT-A3PJ	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.L419V	DO44097	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.L419V	DO26526	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.S408P	TCGA-A5-A1OF	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6752
p.S408P	DO42568	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6752
p.S407P	TCGA-B5-A3FA	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6752
p.S407P	DO52402	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6752
p.D400G	TCGA-E7-A85H	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2222
p.D400G	DO219018	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2222
p.G399E	TCGA-EE-A2M5	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1944
p.G399E	DO37425	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1944
p.S401F	TCGA-EO-A22U	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.25
p.S401F	DO43755	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.25
p.P424H	TCGA-ET-A39R	THCA	TCGA	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1111
p.P424H	DO39552	THCA	ICGC	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1111
p.S414A	TCGA-L5-A8NJ	ESCA	TCGA	AESSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.7588
p.G411S	TCGA-QC-A7B5	SARC	TCGA	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.25
p.G411S	TCGA-QC-A7B5	SARC	TCGA	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.G411S	DO220239	SARC	ICGC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.25
p.G411S	DO220239	SARC	ICGC	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.G399R	DO221118	MALY	ICGC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1944
p.G399R	SIDM00049	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1944
p.G399R	ACH-002233	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1944
p.G399R	DIFI	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1944
p.M397V	SIDM00845	Burkitt's Lymphoma	GDSC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1389
p.M397V	SIDM01519	Head and Neck Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1389
p.M397V	ACH-000992	Head and Neck Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1389
p.S414L	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.7667
p.P409R	SIDM00878	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.3056
p.P409R	SIDM00878	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.P409R	ACH-000930	Breast Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.3056
p.P409R	ACH-000930	Breast Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.P409R	HCC1569	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.3056
p.P409R	HCC1569	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.G405D	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6087
p.G405D	ACH-000611	Lymphoma	CCLE	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6087
p.G405D	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6087
p.Q394H	ACH-000029	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0556

Kaplan plot for APBA1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APBA1

UniProt ID: Q02410

Entrez ID: 320

Protein name: Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for APBA1 in