DegronMD - Q04756(HGFAC)

FUNCTION: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.

GO - Biological processes (BP): blood coagulation [GO:0007596]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]

GO - Molecular function (MF): serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]

GO - Cellular component (CC): cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; rough endoplasmic reticulum [GO:0005791]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
VPSSS	DEG_SPOP_SBC_1	SPOP	Hepatocyte growth factor activator	90:94	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S92W	SIDM01229	Neuroblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7874
p.S92W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7874
p.S92L	TCGA-CV-7568	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7667
p.S92L	DO14160	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7667
p.P91L	DO222887	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.6471
p.P91S	SIDM00007	Other Solid Cancers	GDSC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.5641
p.P91S	ACH-001550	Skin Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.5641
p.P91S	MCC13	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.5641
p.S95G	SIDM00241	Breast Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.3056
p.S95G	ACH-002179	Breast Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.3056
p.S95G	OCUB-M	breast	COSMIC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.3056
p.P86Q	TCGA-CV-7238	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2222
p.P86Q	DO15246	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2222
p.P86Q	DO232838	NACA	ICGC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2222
p.A98T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2222
p.A98T	ACH-000891	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2222
p.P85L	DO232855	NACA	ICGC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.1944
p.G81V	TCGA-BQ-7049	KIRP	TCGA	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.0833
p.G81V	DO20853	KIRP	ICGC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.0833
p.E103K	DO233278	GACA	ICGC	VPSSS	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.0833

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No resistance data available for this Degron.

Kaplan plot for HGFAC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HGFAC

UniProt ID: Q04756

Entrez ID: 3083

Protein name: Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for HGFAC in