DegronMD - Q04912(MST1R)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1013L	TCGA-13-0903	OV	TCGA	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.25
p.S1013L	TCGA-EO-A22U	UCEC	TCGA	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.25
p.D1027N	TCGA-85-A4CL	LUSC	TCGA	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.0833
p.D1027N	TCGA-UY-A9PH	BLCA	TCGA	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.0833
p.G1020C	TCGA-BF-A1PZ	SKCM	TCGA	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.2778
p.S1015Y	TCGA-DA-A1IB	SKCM	TCGA	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.3056
p.R282Q	TCGA-W3-AA1Q	SKCM	TCGA	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.0556
p.R282Q	DO219487	SKCM	ICGC	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.0556
p.E1006K	DO15294	HNSC	ICGC	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.0556
p.I1008M	DO29368	OV	ICGC	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.1111
p.S1015C	DO29508	OV	ICGC	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.3056
p.S1007F	DO229479	SKCA	ICGC	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.0833
p.S1007F	DO51246	SKCM	ICGC	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.0833
p.A285T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1389
p.A285T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1389
p.S284G	ACH-000961	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1111
p.I1026V	ACH-001518	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.1111
p.D1014N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.2778
p.L1013M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1016:1018	Mutation rewiring degron network	0.25
p.R1012C	SW1573	lung	COSMIC	DYR	CBL_MET	1016:1018	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for MST1R in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MST1R

UniProt ID: Q04912

Entrez ID: 4486

Protein name: Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MST1R in