DegronMD - Q06416(POU5F1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y75S	TCGA-50-5930	LUAD	TCGA	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.Y75S	DO25189	LUAD	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.P66L	TCGA-AX-A06F	UCEC	TCGA	PPPY	ITCH	64:67	Mutation altering degron motif	0.6471
p.P66L	TCGA-UF-A71D	HNSC	TCGA	PPPY	ITCH	64:67	Mutation altering degron motif	0.6471
p.P66L	DO52109	HNSC	ICGC	PPPY	ITCH	64:67	Mutation altering degron motif	0.6471
p.P66L	DO41752	UCEC	ICGC	PPPY	ITCH	64:67	Mutation altering degron motif	0.6471
p.A74V	TCGA-CD-A4MJ	STAD	TCGA	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1389
p.A74V	TCGA-CG-5725	STAD	TCGA	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1389
p.A74V	DO47811	STAD	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1389
p.A74V	DO38191	STAD	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1389
p.A74V	SIDM02053	Colorectal Carcinoma	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1389
p.G54D	TCGA-CN-4741	HNSC	TCGA	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0556
p.G54D	DO14313	HNSC	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0556
p.G59R	TCGA-FW-A3R5	SKCM	TCGA	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.G59R	DO37406	SKCM	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.E68K	TCGA-FW-A3R5	SKCM	TCGA	PPPY	ITCH	64:67	Mutation rewiring degron network	0.3056
p.E68K	DO37406	SKCM	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.3056
p.P64S	DO222775	MELA	ICGC	PPPY	ITCH	64:67	Mutation altering degron motif	0.6752
p.G54A	DO46473	OV	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0556
p.C76S	DO229216	THCA	ICGC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.S55F	SIDM00393	Gastric Carcinoma	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.S55F	ACH-001653	Gastric Cancer	CCLE	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.S55F	SK-GT-2	stomach	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.P62L	SIDM00393	Gastric Carcinoma	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.P62L	ACH-001653	Gastric Cancer	CCLE	PPPY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.P62L	SK-GT-2	stomach	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.G71R	SIDM00529	Breast Carcinoma	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.2222
p.G71R	MDA-MB-157	breast	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.2222
p.C76Y	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.C76Y	ACH-000922	Leukemia	CCLE	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.C76Y	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.P64L	SIDM00516	Melanoma	GDSC	PPPY	ITCH	64:67	Mutation altering degron motif	0.7582
p.P64L	ACH-002166	Skin Cancer	CCLE	PPPY	ITCH	64:67	Mutation altering degron motif	0.7582
p.P64L	MZ7-mel	skin	COSMIC	PPPY	ITCH	64:67	Mutation altering degron motif	0.7582
p.S55A	SIDM00844	Burkitt's Lymphoma	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.S55A	SIDM00863	Burkitt's Lymphoma	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.S55A	Raji	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.S55A	EB2	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.P61L	SIDM01159	Other Sarcomas	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.25
p.P61L	ACH-002310	Liposarcoma	CCLE	PPPY	ITCH	64:67	Mutation rewiring degron network	0.25
p.P61L	SW872	soft tissue	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.25
p.G72V	SIDM01042	Breast Carcinoma	GDSC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.G72V	ACH-001065	Breast Cancer	CCLE	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.G72V	EVSA-T	breast	COSMIC	PPPY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.L69F	ACH-000646	Ovarian Cancer	CCLE	PPPY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.G71E	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	64:67	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POU5F1B

UniProt ID: Q06416

Entrez ID: 5462

Protein name: Putative POU domain, class 5, transcription factor 1B (Oct4-pg1) (Octamer-binding protein 3-like) (Octamer-binding transcription factor 3-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POU5F1B in