DegronMD - Q06587(RING1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I126M	TCGA-24-1469	OV	TCGA	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.I126M	DO32626	OV	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.R130H	TCGA-56-8624	LUSC	TCGA	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.R130H	DO45500	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.R127C	TCGA-AP-A1DK	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.R127C	DO42033	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.A149V	TCGA-B5-A3FC	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.A149V	DO41871	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.R146H	TCGA-DF-A2KV	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.R146H	DO219771	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.R146H	SIDM00333	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.R146H	ACH-000988	Endometrial/Uterine Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.R146H	MFE-319	endometrium	COSMIC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.S140N	TCGA-E6-A1LX	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.818
p.S140N	DO41020	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.818
p.R127H	TCGA-KK-A59V	PRAD	TCGA	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.R127H	DO51346	PRAD	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.R130C	DO234441	ESAD	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.A136T	DO233261	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7139
p.H132Y	DO49679	LIAD	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2222
p.S140R	DO229188	THCA	ICGC	ALSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.8538

Kaplan plot for RING1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RING1

UniProt ID: Q06587

Entrez ID: 6015

Protein name: E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RING1 in