DegronMD - Q07157(TJP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E957V	TCGA-13-1497	OV	TCGA	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.2778
p.E957V	TCGA-13-1497	OV	TCGA	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.1944
p.E957V	DO31959	OV	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.2778
p.E957V	DO31959	OV	ICGC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.1944
p.S1577L	TCGA-19-5956	GBM	TCGA	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.0556
p.S1577L	TCGA-EO-A22R	UCEC	TCGA	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.0556
p.S1577L	DO13863	GBM	ICGC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.0556
p.S1577L	DO42713	UCEC	ICGC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.0556
p.S968L	TCGA-55-8204	LUAD	TCGA	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.6667
p.S968L	TCGA-55-8204	LUAD	TCGA	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.6111
p.S968L	TCGA-55-8204	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.7222
p.S968L	DO45322	LUAD	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.6667
p.S968L	DO45322	LUAD	ICGC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.6111
p.S968L	DO45322	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.7222
p.T1528A	TCGA-5P-A9JW	KIRP	TCGA	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation blocking phosphorylation signal	0.6944
p.T1528A	DO223943	KIRP	ICGC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation blocking phosphorylation signal	0.6944
p.E935Q	TCGA-77-8136	LUSC	TCGA	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.E935Q	DO26593	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.V945F	TCGA-85-7710	LUSC	TCGA	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.V945F	DO26826	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.R1541H	TCGA-A5-A0G2	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.1667
p.R1541H	DO41235	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.1667
p.E958K	TCGA-A5-A0G2	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.3056
p.E958K	TCGA-A5-A0G2	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.2222
p.E958K	DO41235	UCEC	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.3056
p.E958K	DO41235	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.2222
p.S1594P	TCGA-A5-A0VP	UCEC	TCGA	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation altering degron motif	0.6752
p.S1594P	DO42600	UCEC	ICGC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation altering degron motif	0.6752
p.R265W	TCGA-AA-3864	COAD	TCGA	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation altering degron motif	0.8634
p.R265W	TCGA-AA-3864	COAD	TCGA	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.7523
p.R265W	DO8490	COAD	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation altering degron motif	0.8634
p.R265W	DO8490	COAD	ICGC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.7523
p.R265W	DO227549	COCA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation altering degron motif	0.8634
p.R265W	DO227549	COCA	ICGC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.7523
p.L862F	TCGA-AP-A0LJ	UCEC	TCGA	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.2222
p.L862F	DO42145	UCEC	ICGC	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.2222
p.P977L	TCGA-AP-A1DK	UCEC	TCGA	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation altering degron motif	0.7582
p.P977L	DO42033	UCEC	ICGC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation altering degron motif	0.7582
p.S1535Y	TCGA-AP-A1DV	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation altering degron motif	0.712
p.S1535Y	DO43186	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation altering degron motif	0.712
p.G254C	TCGA-AX-A063	UCEC	TCGA	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.0556
p.G254C	TCGA-AX-A063	UCEC	TCGA	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation rewiring degron network	0.0833
p.G254C	DO42201	UCEC	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.0556
p.G254C	DO42201	UCEC	ICGC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation rewiring degron network	0.0833
p.N946Y	TCGA-B0-5119	KIRC	TCGA	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2222
p.N946Y	DO18721	KIRC	ICGC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2222
p.Y967H	TCGA-B5-A3FA	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.6944
p.Y967H	TCGA-B5-A3FA	UCEC	TCGA	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.5833
p.Y967H	TCGA-B5-A3FA	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.75
p.Y967H	DO52402	UCEC	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.6944
p.Y967H	DO52402	UCEC	ICGC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.5833
p.Y967H	DO52402	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.75
p.Y967H	HT-144	skin	COSMIC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.6944
p.Y967H	HT-144	skin	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.5833
p.Y967H	HT-144	skin	COSMIC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.75
p.A1536V	TCGA-BG-A222	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.3056
p.A1536V	DO42977	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.3056
p.Q1090H	TCGA-D8-A27M	BRCA	TCGA	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.3056
p.Q1090H	TCGA-D8-A27M	BRCA	TCGA	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.3056
p.Q1090H	DO1380	BRCA	ICGC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.3056
p.Q1090H	DO1380	BRCA	ICGC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.3056
p.P959L	TCGA-DD-A1EH	LIHC	TCGA	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation altering degron motif	0.6471
p.P959L	DO22986	LIHC	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation altering degron motif	0.6471
p.P963S	TCGA-EE-A29E	SKCM	TCGA	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation altering degron motif	0.5641
p.P963S	TCGA-EE-A29E	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	962:966	Mutation altering degron motif	0.5641
p.P963S	DO37831	SKCM	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation altering degron motif	0.5641
p.P963S	DO37831	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation altering degron motif	0.5641
p.N937S	TCGA-EI-6917	READ	TCGA	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.3056
p.N937S	DO36881	READ	ICGC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.3056
p.S878F	TCGA-EK-A2RJ	CESC	TCGA	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.1667
p.S878F	DO49950	CESC	ICGC	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.1667
p.L932I	TCGA-EO-A22R	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1667
p.L932I	DO42713	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1667
p.S973Y	TCGA-EO-A22U	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.5278
p.S973Y	TCGA-EO-A22U	UCEC	TCGA	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.75
p.S973Y	TCGA-EO-A22U	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.5833
p.S973Y	DO43755	UCEC	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.5278
p.S973Y	DO43755	UCEC	ICGC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.75
p.S973Y	DO43755	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.5833
p.S973Y	SIDM00193	Colorectal Carcinoma	GDSC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.5278
p.S973Y	SIDM00193	Colorectal Carcinoma	GDSC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.75
p.S973Y	SIDM00193	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.5833
p.S973Y	ACH-000991	Colon/Colorectal Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.5278
p.S973Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.75
p.S973Y	ACH-000991	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.5833
p.S973Y	SNU-81	large intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation blocking phosphorylation signal	0.5278
p.S973Y	SNU-81	large intestine	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation blocking phosphorylation signal	0.75
p.S973Y	SNU-81	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation blocking phosphorylation signal	0.5833
p.R819H	TCGA-FI-A2D0	UCEC	TCGA	LDLHDD	LIG_APCC_ABBA_1	813:818	Mutation rewiring degron network	0.3056
p.R819H	DO50407	ESAD	ICGC	LDLHDD	LIG_APCC_ABBA_1	813:818	Mutation rewiring degron network	0.3056
p.R819H	DO43891	UCEC	ICGC	LDLHDD	LIG_APCC_ABBA_1	813:818	Mutation rewiring degron network	0.3056
p.I1595V	TCGA-IG-A97I	ESCA	TCGA	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation altering degron motif	0.5965
p.P272L	DO225337	BRCA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation altering degron motif	0.6471
p.P272L	DO225337	BRCA	ICGC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.7582
p.L951V	DO222884	COCA	ICGC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.1111
p.L951V	DO222884	COCA	ICGC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.0833
p.Q856E	DO222675	ESCA	ICGC	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.0556
p.R1541C	DO233245	GACA	ICGC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.1667
p.L932F	DO233247	GACA	ICGC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1667
p.N282D	DO233871	GACA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.0556
p.N282D	DO233871	GACA	ICGC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation rewiring degron network	0.1111
p.H1596Q	DO23152	LINC	ICGC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation altering degron motif	0.7582
p.H1596Q	DO45081	LINC	ICGC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation altering degron motif	0.7582
p.S284T	DO231742	LINC	ICGC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation blocking phosphorylation signal	0.5
p.D806N	DO45159	LIRI	ICGC	LDLHDD	LIG_APCC_ABBA_1	813:818	Mutation rewiring degron network	0.1389
p.H816R	DO231127	LUSC	ICGC	LDLHDD	LIG_APCC_ABBA_1	813:818	Mutation altering degron motif	0.8244
p.L269S	DO229479	SKCA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation altering degron motif	0.6556
p.L269S	DO229479	SKCA	ICGC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.6556
p.S966A	SIDM02021	Esophageal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation altering degron motif	0.87
p.R1537Q	SIDM01282	Colorectal Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.2778
p.R1537Q	SIDM00841	Colorectal Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.2778
p.R1537Q	SW620	large intestine	COSMIC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.2778
p.S978N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation altering degron motif	0.7069
p.S978N	SIDM00785	Acute Myeloid Leukemia	GDSC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation altering degron motif	0.7069
p.R876W	SIDM00993	Plasma Cell Myeloma	GDSC	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.2222
p.R876W	AMO-1	haematopoietic and lymphoid tissue	COSMIC	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.2222
p.E1089D	SIDM00845	Burkitt's Lymphoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation altering degron motif	0.5647
p.E1089D	SIDM00845	Burkitt's Lymphoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation altering degron motif	0.5647
p.T942A	SIDM00845	Burkitt's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.7139
p.T942A	SIDM01519	Head and Neck Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.7139
p.N937T	SIDM00845	Burkitt's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.3056
p.N937T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.3056
p.N937T	SIDM01519	Head and Neck Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.3056
p.R1083C	SIDM01176	B-Lymphoblastic Leukemia	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation altering degron motif	0.8301
p.R1083C	SIDM01164	Glioma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation altering degron motif	0.8301
p.R1083C	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation altering degron motif	0.8301
p.R1077H	SIDM01145	Gastric Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077H	SIDM01145	Gastric Carcinoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077H	SIDM01181	Hepatocellular Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077H	SIDM01181	Hepatocellular Carcinoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077H	SIDM01368	Gastric Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077H	SIDM01368	Gastric Carcinoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077H	SIDM01394	Kidney Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077H	SIDM01394	Kidney Carcinoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077H	SIDM01574	Plasma Cell Myeloma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077H	SIDM01574	Plasma Cell Myeloma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.S933L	SIDM00889	Cervical Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	938:942	Mutation blocking phosphorylation signal	0.6389
p.S933L	ACH-001333	Cervical Cancer	CCLE	PASST	DEG_SPOP_SBC_1	938:942	Mutation blocking phosphorylation signal	0.6389
p.S933L	C-33-A	cervix	COSMIC	PASST	DEG_SPOP_SBC_1	938:942	Mutation blocking phosphorylation signal	0.6389
p.R1077S	SIDM00097	Breast Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077S	SIDM00097	Breast Carcinoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077S	SIDM00861	Ovarian Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077S	SIDM00861	Ovarian Carcinoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077S	SIDM01613	Colorectal Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077S	SIDM01613	Colorectal Carcinoma	GDSC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077S	ES-2	ovary	COSMIC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077S	ES-2	ovary	COSMIC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.R1077S	T47D	breast	COSMIC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1389
p.R1077S	T47D	breast	COSMIC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1667
p.D273H	SIDM00621	Ewing's Sarcoma	GDSC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.7688
p.D273H	EW-13	bone	COSMIC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.7688
p.Y983H	ACH-000322	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.25
p.Y983H	ACH-002458	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.25
p.Y983H	ACH-002459	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.25
p.Y983H	ACH-002460	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.25
p.Y983H	HT-144	skin	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.25
p.A1078T	ACH-000674	Gastric Cancer	CCLE	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1667
p.A1078T	ACH-000674	Gastric Cancer	CCLE	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1944
p.A1078T	NUGC-4	stomach	COSMIC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.1667
p.A1078T	NUGC-4	stomach	COSMIC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.1944
p.R880W	ACH-000838	Myeloma	CCLE	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.1111
p.R880W	AMO-1	haematopoietic and lymphoid tissue	COSMIC	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.1111
p.P933L	ACH-000896	Bladder Cancer	CCLE	PASST	DEG_SPOP_SBC_1	938:942	Mutation blocking phosphorylation signal	0.6389
p.P933L	647-V	urinary tract	COSMIC	PASST	DEG_SPOP_SBC_1	938:942	Mutation blocking phosphorylation signal	0.6389
p.V970A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.1667
p.V970A	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.2222
p.V970A	ACH-000978	Endometrial/Uterine Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.2222
p.V970A	EN	endometrium	COSMIC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.1667
p.V970A	EN	endometrium	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.2222
p.V970A	EN	endometrium	COSMIC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.2222
p.P1583T	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2222
p.P1583T	ACH-000994	Endometrial/Uterine Cancer	CCLE	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.0556
p.S975I	ACH-001081	Colon/Colorectal Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation altering degron motif	0.7341
p.S975I	HCC2998	large intestine	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation altering degron motif	0.7341
p.R269W	ACH-001184	Sarcoma	CCLE	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation altering degron motif	0.8634
p.R269W	ACH-001184	Sarcoma	CCLE	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation altering degron motif	0.8634
p.D863E	ACH-001977	Primary	CCLE	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.25
p.D277H	ACH-002113	Bone Cancer	CCLE	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation blocking phosphorylation signal	0.6389
p.D277H	ACH-002113	Bone Cancer	CCLE	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation blocking phosphorylation signal	0.6944
p.D277H	EW-13	bone	COSMIC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation blocking phosphorylation signal	0.6389
p.D277H	EW-13	bone	COSMIC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation blocking phosphorylation signal	0.6944
p.E1589K	SAT	upper aerodigestive tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation altering degron motif	0.7022
p.E1589K	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation altering degron motif	0.7022
p.E1589K	BHY	upper aerodigestive tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation altering degron motif	0.7022
p.E1589K	SCH	stomach	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation altering degron motif	0.7022
p.E1589K	TE-6	oesophagus	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation altering degron motif	0.7022
p.E1589K	TC-YIK	cervix	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation altering degron motif	0.7022
p.E1589K	HuO9	bone	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation altering degron motif	0.7022
p.S971I	HCC2998	large intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.1389
p.S971I	HCC2998	large intestine	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.25
p.S971I	HCC2998	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.1944
p.D261H	EW-13	bone	COSMIC	ERATLLNVP	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.25
p.D261H	EW-13	bone	COSMIC	DERATLLNVPDL	DEG_COP1_1	263:274	Mutation rewiring degron network	0.2778
p.R985S	T47D	breast	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.1944
p.R985S	ES-2	ovary	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation rewiring degron network	0.1944
p.E1585K	SCH	stomach	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2778
p.E1585K	SCH	stomach	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.E1585K	TE-6	oesophagus	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2778
p.E1585K	TE-6	oesophagus	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.E1585K	BHY	upper aerodigestive tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2778
p.E1585K	BHY	upper aerodigestive tract	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.E1585K	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2778
p.E1585K	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.E1585K	HuO9	bone	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2778
p.E1585K	HuO9	bone	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.E1585K	TC-YIK	cervix	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2778
p.E1585K	TC-YIK	cervix	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.E1585K	SAT	upper aerodigestive tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	1587:1592	Mutation rewiring degron network	0.2778
p.E1585K	SAT	upper aerodigestive tract	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.S959I	HCC2998	large intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation altering degron motif	0.7341
p.V954A	EN	endometrium	COSMIC	PTPAPS	DEG_SCF_FBW7_1	959:964	Mutation rewiring degron network	0.1944
p.V954A	EN	endometrium	COSMIC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation rewiring degron network	0.1111
p.E1530A	NCI-H1304	lung	COSMIC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.3056
p.Y1099H	GP5d	large intestine	COSMIC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation rewiring degron network	0.0556
p.Y1099H	GP5d	large intestine	COSMIC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation rewiring degron network	0.0556
p.T828N	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	LDLHDD	LIG_APCC_ABBA_1	813:818	Mutation blocking phosphorylation signal	0.5
p.G1598C	MDA-MB-231	breast	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation altering degron motif	0.76
p.A1074T	NUGC-4	stomach	COSMIC	VPMYEE	LIG_APCC_ABBA_1	1084:1089	Mutation blocking phosphorylation signal	0.5
p.A1074T	NUGC-4	stomach	COSMIC	RVPMYEE	LIG_APCC_ABBAyCdc20_2	1083:1089	Mutation blocking phosphorylation signal	0.5278
p.V1606M	MCC13	skin	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1111
p.Y979H	HT-144	skin	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	974:980	Mutation altering degron motif	0.7229
p.E1530K	LP-1	haematopoietic and lymphoid tissue	COSMIC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation rewiring degron network	0.3056
p.R864W	AMO-1	haematopoietic and lymphoid tissue	COSMIC	VGTPPES	DEG_SCF_FBW7_1	866:872	Mutation rewiring degron network	0.2778
p.P929L	647-V	urinary tract	COSMIC	PASST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.0833
p.P1604H	NCI-H1048	lung	COSMIC	FSIHAE	LIG_APCC_ABBA_1	1593:1598	Mutation rewiring degron network	0.1667
p.E1542A	NCI-H1304	lung	COSMIC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation substituting flanking lysine	0.25
p.V966A	EN	endometrium	COSMIC	APSTS	DEG_SPOP_SBC_1	962:966	Mutation altering degron motif	0.6936
p.E1542K	LP-1	haematopoietic and lymphoid tissue	COSMIC	PYTSS	DEG_SPOP_SBC_1	1531:1535	Mutation substituting flanking lysine	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TJP1

UniProt ID: Q07157

Entrez ID: 7082

Protein name: Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TJP1 in