DegronMD - Q08188(TGM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T464R	TCGA-13-1499	OV	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.25
p.T464R	DO31563	OV	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.25
p.L460F	TCGA-76-4928	GBM	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1389
p.L460F	DO14145	GBM	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1389
p.M472V	TCGA-CJ-4901	KIRC	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.3056
p.M472V	DO16276	KIRC	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.3056
p.T469M	TCGA-CU-A3QU	BLCA	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.7423
p.T469M	TCGA-EY-A215	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.7423
p.T469M	DO587	BLCA	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.7423
p.T469M	DO42665	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.7423
p.A468T	TCGA-CV-7242	HNSC	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.6028
p.A468T	DO233823	GACA	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.6028
p.A468T	DO14974	HNSC	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.6028
p.A468T	DO46859	RECA	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.6028
p.A468T	SIDM02026	Colorectal Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.6028
p.T464K	TCGA-L9-A8F4	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.25
p.T464K	DO49876	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.25
p.E477G	TCGA-RQ-A68N	DLBC	TCGA	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1667
p.E477G	DO219921	DLBC	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1667
p.A468V	DO234199	ESAD	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.5825
p.A468V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.5825
p.A468V	SIDM00628	Breast Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.5825
p.A468V	SIDM01318	Hepatocellular Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.5825
p.E475K	DO220906	MELA	ICGC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222
p.M472I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.3056
p.M472I	ACH-000995	Leukemia	CCLE	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.3056
p.T464M	SIDM01109	Other Sarcomas	GDSC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.25
p.T464M	SIDM01706	Hodgkin's Lymphoma	GDSC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.25
p.T464M	SK-LMS-1	soft tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.25

Kaplan plot for TGM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGM3

UniProt ID: Q08188

Entrez ID: 7053

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGM3 in