DegronMD - Q0P670(SPEM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T485I	SIDM00377	Other Sarcomas	GDSC	PASTS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.8189
p.T485I	SKN	soft tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.8189
p.S491Y	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1944
p.S491Y	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1944
p.P482Q	SIDM00094	Kidney Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7035
p.P482Q	SN12C	kidney	COSMIC	PASTS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7035
p.E409K	SIDM00014	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.E409K	LIM1215	large intestine	COSMIC	PLTTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.W388C	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0833
p.W388C	NCI-H1793	lung	COSMIC	PLTTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons