DegronMD - Q0VF49(KIAA2012)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F215I	SIDM00845	Burkitt's Lymphoma	GDSC	PPKY	ITCH	206:209	Mutation rewiring degron network	0.1667
p.Y209H	SIDM00041	Gastric Carcinoma	GDSC	PPKY	ITCH	206:209	Mutation altering degron motif	0.7229
p.Y209H	SIDM00311	Mesothelioma	GDSC	PPKY	ITCH	206:209	Mutation altering degron motif	0.7229
p.Y209H	SIDM01120	Other Solid Cancers	GDSC	PPKY	ITCH	206:209	Mutation altering degron motif	0.7229
p.Y209H	SIDM00125	Kidney Carcinoma	GDSC	PPKY	ITCH	206:209	Mutation altering degron motif	0.7229
p.Y209H	H2810	pleura	COSMIC	PPKY	ITCH	206:209	Mutation altering degron motif	0.7229
p.Y209H	786-0	kidney	COSMIC	PPKY	ITCH	206:209	Mutation altering degron motif	0.7229
p.Y209H	NCI-H720	lung	COSMIC	PPKY	ITCH	206:209	Mutation altering degron motif	0.7229

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons