DegronMD - Q10587(TEF)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q150H	TCGA-AX-A06F	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1944
p.V155M	TCGA-DU-6392	LGG	TCGA	PPSSS	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.0556
p.S137F	TCGA-EE-A3J7	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7982
p.S136C	TCGA-ZF-AA4X	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7541
p.N145S	DO219013	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.7069
p.C146Y	DO222877	COCA	ICGC	ASSST	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1111
p.C146Y	DO222877	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.3056
p.V125M	DO22237	LGG	ICGC	ASSST	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.0833
p.D143Y	DO229029	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.7325
p.S127R	DO233298	NACA	ICGC	ASSST	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.S131F	DO219456	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	134:138	Mutation substituting flanking lysine	0.3611
p.S131F	DO219456	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	141:145	Mutation substituting flanking lysine	0.1667
p.S135R	SIDM00867	Glioblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.6316
p.S135R	ACH-000863	Brain Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.6316
p.S135R	DBTRG-05MG	central nervous system	COSMIC	ASSST	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.6316

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons