DegronMD - Q12837(POU4F2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A166V	TCGA-2W-A8YY	CESC	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0833
p.A166V	TCGA-BR-8686	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0833
p.A166V	DO223732	CESC	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0833
p.A166V	DO48036	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0833
p.S37W	TCGA-77-7141	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.S37W	TCGA-DK-A6B1	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.S37W	DO48534	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.S37W	DO26450	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.M145L	TCGA-85-8584	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1111
p.M145L	DO45438	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1111
p.A166T	TCGA-A5-A0VP	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0833
p.A166T	DO42600	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0833
p.A38T	TCGA-AU-3779	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0833
p.A38T	DO8626	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0833
p.A154T	TCGA-AX-A0J0	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6028
p.A154T	TCGA-B5-A11E	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6028
p.A154T	TCGA-G4-6628	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6028
p.A154T	DO10132	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6028
p.A154T	DO229523	PRAD	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6028
p.A154T	DO41644	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6028
p.A154T	DO41133	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6028
p.M145I	TCGA-B5-A0JY	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1111
p.M145I	DO229029	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1111
p.M145I	DO43041	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1111
p.S162W	TCGA-BH-A0B6	BRCA	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1944
p.S162W	DO2641	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1944
p.P164S	TCGA-EE-A29M	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1389
p.P164S	DO37404	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1389
p.P149Q	TCGA-EE-A2A6	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.2222
p.P149Q	DO37591	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.2222
p.S43L	DO224768	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation blocking phosphorylation signal	0.6667
p.S158L	DO8898	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.3056
p.I40T	DO229346	LAML	ICGC	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1389
p.A154S	DO229029	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6477
p.A41T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.A41T	ACH-000924	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.A41T	NCI-H2172	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.S157T	ACH-001130	Lymphoma	CCLE	AASSS	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6005
p.I148M	ACH-001623	Brain Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1944

Kaplan plot for POU4F2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POU4F2

UniProt ID: Q12837

Entrez ID: 5458

Protein name: POU domain, class 4, transcription factor 2 (Brain-specific homeobox/POU domain protein 3B) (Brain-3B) (Brn-3B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POU4F2 in