DegronMD - Q12952(FOXL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A299T	TCGA-19-5951	GBM	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7139
p.A299T	DO14067	GBM	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7139
p.F308L	TCGA-2F-A9KP	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.F308L	DO51860	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.N309K	TCGA-39-5011	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.N309K	DO27532	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.G291A	TCGA-98-8022	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.G291A	DO26934	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.A300V	TCGA-D3-A8GB	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5825
p.A300V	DO50280	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5825
p.R305C	TCGA-D6-A4ZB	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2778
p.R305C	DO44446	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2778
p.S303C	TCGA-EE-A2GO	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7541
p.S303C	DO37823	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7541
p.F308V	TCGA-EO-A22R	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.F308V	DO42713	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.L297F	TCGA-EO-A3AU	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2778
p.L297F	DO43827	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2778
p.G290S	DO227999	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.G294C	DO233238	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.R292H	DO233888	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.M313I	DO228948	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.L312M	DO231830	LINC	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.S311F	DO222572	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.G290R	SIDM01123	Prostate Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.G290R	ACH-000177	Prostate Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.G290R	NCI-H660	prostate	COSMIC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.A299V	SIDM00373	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5825
p.A299V	ACH-000974	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5825
p.A299V	ACH-002026	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5825
p.A299V	SNG-M	endometrium	COSMIC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5825
p.R305G	SIDM00393	Gastric Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2778
p.R305G	ACH-001653	Gastric Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2778
p.R305G	SK-GT-2	stomach	COSMIC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2778
p.L298P	SIDM00327	Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.L298P	ACH-000754	Lymphoma	CCLE	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.L298P	L-428	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.A310V	ACH-000985	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389

Kaplan plot for FOXL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXL1

UniProt ID: Q12952

Entrez ID: 2300

Protein name: Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXL1 in