DegronMD - Q13405(MRPL49)

MRPL49

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T29A	TCGA-A5-A0VP	UCEC	TCGA	PPDY	ITCH	32:35	Mutation rewiring degron network	0.25
p.T29A	DO42600	UCEC	ICGC	PPDY	ITCH	32:35	Mutation rewiring degron network	0.25
p.Q30H	TCGA-EE-A17Z	SKCM	TCGA	PPDY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.Q30H	DO37921	SKCM	ICGC	PPDY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.E44K	DO48457	BLCA	ICGC	PPDY	ITCH	32:35	Mutation rewiring degron network	0.0833
p.P45L	DO44086	COAD	ICGC	PPDY	ITCH	32:35	Mutation blocking phosphorylation signal	0.5
p.G31C	SIDM00596	Endometrial Carcinoma	GDSC	PPDY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.G31C	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPDY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.G31C	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPDY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.G31C	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPDY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.G31C	HEC-1	endometrium	COSMIC	PPDY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.D37Y	ACH-000916	Lung Cancer	CCLE	PPDY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.D37Y	NCI-H1573	lung	COSMIC	PPDY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.Y36C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPDY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.D37N	ACH-001353	Pancreatic Cancer	CCLE	PPDY	ITCH	32:35	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc