DegronMD - Q13470(TNK1)

TNK1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G535C	TCGA-A3-3382	KIRC	TCGA	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1667
p.R539H	TCGA-B5-A3FC	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.Q531H	TCGA-D3-A1Q3	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.0556
p.R554M	TCGA-D3-A2JG	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.0833
p.R549M	DO47613	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2222
p.W554R	DO38715	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.0833
p.R534H	DO41871	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1389
p.S546C	SIDM00969	Ovarian Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation blocking phosphorylation signal	0.75
p.S546C	SIDM01133	Other Solid Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation blocking phosphorylation signal	0.75
p.S546C	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	541:545	Mutation blocking phosphorylation signal	0.75

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*NOTE: the Kaplan plots were collected from OncoLnc