DegronMD - Q13515(BFSP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E37K	TCGA-34-2596	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.25
p.E37K	TCGA-DX-A8BP	SARC	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.25
p.E37K	DO26508	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.25
p.E37K	DO220056	SARC	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.25
p.S42F	TCGA-56-8305	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1111
p.S42F	DO223725	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1111
p.R28M	TCGA-66-2795	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2778
p.R28M	DO26710	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2778
p.R23C	TCGA-EI-6917	READ	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.R23C	TCGA-VQ-A8P2	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.R23C	DO36881	READ	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.R23C	DO51761	STAD	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.R23C	ACH-001419	Breast Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.A25E	TCGA-G4-6315	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.A25E	DO9522	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.P30S	TCGA-XK-AAIW	PRAD	TCGA	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.6752
p.P30S	DO51407	PRAD	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.6752
p.E37D	DO228974	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.25
p.P39S	SIDM00198	Ewing's Sarcoma	GDSC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.P39S	ACH-002114	Bone Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.P39S	EW-16	bone	COSMIC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.R23H	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.R23H	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.R23H	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.A25V	SIDM01608	Endometrial Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.A25V	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.S26P	ACH-000572	Skin Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	30:34	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for BFSP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BFSP2

UniProt ID: Q13515

Entrez ID: 8419

Protein name: Phakinin (49 kDa cytoskeletal protein) (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 47) (CP47) (Lens fiber cell beaded filament protein CP 49) (CP49) (Lens intermediate filament-like light) (LIFL-L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BFSP2 in