DegronMD - Q13571(LAPTM5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P250T	TCGA-43-2578	LUSC	TCGA	PPPY	ITCH	256:259	Mutation rewiring degron network	0.1667
p.P250T	DO26662	LUSC	ICGC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.1667
p.A255S	TCGA-AP-A059	UCEC	TCGA	PPPY	ITCH	256:259	Mutation rewiring degron network	0.3056
p.A255S	DO41361	UCEC	ICGC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.3056
p.E261D	TCGA-D3-A2JD	SKCM	TCGA	PPPY	ITCH	256:259	Mutation rewiring degron network	0.2778
p.E261D	DO37543	SKCM	ICGC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.2778
p.P246T	TCGA-D3-A8GI	SKCM	TCGA	PPPY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.P246T	DO50284	SKCM	ICGC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.P256Q	TCGA-EE-A184	SKCM	TCGA	PPPY	ITCH	256:259	Mutation altering degron motif	0.7035
p.P256Q	DO47442	SKCM	ICGC	PPPY	ITCH	256:259	Mutation altering degron motif	0.7035
p.S247L	TCGA-FR-A8YC	SKCM	TCGA	PPPY	ITCH	256:259	Mutation blocking phosphorylation signal	0.5278
p.S247L	DO50301	SKCM	ICGC	PPPY	ITCH	256:259	Mutation blocking phosphorylation signal	0.5278
p.G253S	TCGA-FW-A3R5	SKCM	TCGA	PPPY	ITCH	256:259	Mutation rewiring degron network	0.25
p.G253S	DO37406	SKCM	ICGC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.25
p.P257T	DO228974	LICA	ICGC	PPPY	ITCH	256:259	Mutation altering degron motif	0.7031
p.E251K	DO220857	MELA	ICGC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.1944
p.P257L	DO222837	MELA	ICGC	PPPY	ITCH	256:259	Mutation altering degron motif	0.7582
p.T249A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.1389
p.T249A	SIDM00793	Burkitt's Lymphoma	GDSC	PPPY	ITCH	256:259	Mutation rewiring degron network	0.1389
p.A255V	ACH-001389	Breast Cancer	CCLE	PPPY	ITCH	256:259	Mutation rewiring degron network	0.3056

Kaplan plot for LAPTM5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAPTM5

UniProt ID: Q13571

Entrez ID: 7805

Protein name: Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAPTM5 in