DegronMD - Q13613(MTMR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A643T	TCGA-2W-A8YY	CESC	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7139
p.A643T	TCGA-AX-A0J1	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7139
p.A643T	DO223732	CESC	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7139
p.A643T	DO41199	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7139
p.A643T	ACH-000187	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7139
p.A643T	COR-L311	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7139
p.R650Q	TCGA-BR-4362	STAD	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.R650Q	DO38336	STAD	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.V639A	TCGA-DI-A1BU	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.V639A	DO42023	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.R642C	TCGA-EY-A548	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.R642C	DO48173	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.R642C	ACH-000568	Breast Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.R642C	UACC-812	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.G651D	TCGA-GN-A8LK	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.G651D	DO51259	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.R642H	TCGA-WQ-A9G7	LIHC	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.R642H	DO52326	LIHC	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.S648P	TCGA-XF-AAMY	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation blocking phosphorylation signal	0.75
p.S648P	DO219050	BLCA	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation blocking phosphorylation signal	0.75
p.T641M	DO228928	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.T641M	ACH-000958	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.T641M	SW48	large intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.R637L	DO228976	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1667
p.V644F	DO229257	THCA	ICGC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.5957
p.A651T	SIDM00509	Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.A651T	COR-L311	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.A634V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0833
p.A634V	NCI-H1155	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0833
p.T649M	SIDM00837	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.T649M	SW48	large intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.R650C	SIDM01187	Breast Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.R650C	UACC-812	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25

Kaplan plot for MTMR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTMR1

UniProt ID: Q13613

Entrez ID: 8776

Protein name: Myotubularin-related protein 1 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTMR1 in