DegronMD - Q14209(E2F2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L318F	TCGA-BR-6452	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.3056
p.L318F	DO38404	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.3056
p.P313L	TCGA-EE-A180	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1667
p.P313L	DO220859	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1667
p.P313L	DO47537	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1667
p.E315K	TCGA-MX-A5UJ	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2222
p.E315K	DO48547	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2222
p.M342I	TCGA-SJ-A6ZI	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.M342I	DO219784	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.S314F	TCGA-W3-AA21	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1944
p.S314F	DO51278	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1944
p.P310T	DO229037	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.S340R	DO229009	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.S314P	DO222880	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1944
p.D311G	DO229259	THCA	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1111
p.Q332R	DO229272	THCA	ICGC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.Q332R	DO229272	THCA	ICGC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.3056
p.E343A	DO229208	THCA	ICGC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.D338N	SIDM00263	Ewing's Sarcoma	GDSC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.3056
p.D338N	SIDM00638	Cervical Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.3056
p.P310L	SIDM00847	Rhabdomyosarcoma	GDSC	PSTST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.S336C	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7541
p.S336C	ACH-000343	Lung Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7541
p.S336C	NCI-H522	lung	COSMIC	PSSST	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7541

Kaplan plot for E2F2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

E2F2

UniProt ID: Q14209

Entrez ID: 1870

Protein name: Transcription factor E2F2 (E2F-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for E2F2 in