DegronMD - Q14247(CTTN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D455Y	TCGA-44-6778	LUAD	TCGA	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.3056
p.Y452C	TCGA-AG-A002	READ	TCGA	DYR	CBL_MET	452:454	Mutation altering degron motif	0.7087
p.L456M	TCGA-AJ-A3EK	UCEC	TCGA	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.2778
p.Y464C	TCGA-AX-A063	UCEC	TCGA	DYR	CBL_MET	452:454	Mutation blocking phosphorylation signal	0.5
p.V461A	TCGA-BR-8589	STAD	TCGA	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.1389
p.D450N	TCGA-EA-A1QT	CESC	TCGA	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.2778
p.D450N	SIDM00615	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.2778
p.D450N	JHH-6	liver	COSMIC	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.2778
p.A462T	TCGA-EA-A410	CESC	TCGA	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.1111
p.P443S	TCGA-GN-A4U8	SKCM	TCGA	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.0833
p.I458S	TCGA-OL-A5DA	BRCA	TCGA	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.2222
p.A450G	DO51922	BLCA	ICGC	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.2778
p.R454Q	DO234154	ESAD	ICGC	DYR	CBL_MET	452:454	Mutation altering degron motif	0.7329
p.L462Q	DO234320	ESAD	ICGC	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.1111
p.A463P	DO24411	LUAD	ICGC	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.0833
p.G461S	DO38348	STAD	ICGC	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.1389
p.A450V	DO41638	UCEC	ICGC	DYR	CBL_MET	452:454	Mutation rewiring degron network	0.2778
p.E453K	SIDM00882	Breast Carcinoma	GDSC	DYR	CBL_MET	452:454	Mutation altering degron motif	0.7022
p.E453K	ACH-000277	Breast Cancer	CCLE	DYR	CBL_MET	452:454	Mutation altering degron motif	0.7022
p.E453K	HCC1419	breast	COSMIC	DYR	CBL_MET	452:454	Mutation altering degron motif	0.7022

Kaplan plot for CTTN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTTN

UniProt ID: Q14247

Entrez ID: 2017

Protein name: Src substrate cortactin (Amplaxin) (Oncogene EMS1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CTTN in