FZD2
UniProt ID: Q14332
Entrez ID: 2535
Protein name: Frizzled-2 (Fz-2) (hFz2) (FzE2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A ...
FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. {ECO:0000269|PubMed:25759469}.; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286). TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286). {ECO:0000269|PubMed:27680706, ECO:0000269|PubMed:29748286}.
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GO - Biological processes (BP):
canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; epithelial cell differentiation [GO:0030855]; hard palate development [GO:0060022]; inner ear receptor cell development [GO:0060119]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003...
canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; epithelial cell differentiation [GO:0030855]; hard palate development [GO:0060022]; inner ear receptor cell development [GO:0060119]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003150]; neuron differentiation [GO:0030182]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; sensory perception of smell [GO:0007608]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]
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GO - Molecular function (MF):
G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt-activated receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]...
G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt-activated receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
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GO - Cellular component (CC):
clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]...
clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
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FZD2
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Kaplan plot for FZD2 in
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*NOTE: the Kaplan plots were collected from OncoLnc