DegronMD - Q14642(INPP5A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D320H	TCGA-43-6770	LUSC	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.2222
p.D320H	DO27644	LUSC	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.2222
p.E337K	TCGA-86-8674	LUAD	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.0556
p.E337K	DO25535	LUAD	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.0556
p.R334H	TCGA-AP-A1DR	UCEC	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1389
p.R334H	DO43747	UCEC	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1389
p.A333T	TCGA-AU-6004	COAD	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1667
p.A333T	TCGA-AX-A1CE	UCEC	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1667
p.A333T	DO7780	COAD	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1667
p.A333T	DO42280	UCEC	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1667
p.I321V	TCGA-D7-6822	STAD	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.25
p.I321V	DO38423	STAD	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.25
p.P328S	TCGA-EB-A85J	SKCM	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328S	DO50297	SKCM	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328S	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328S	ACH-000667	Lung Cancer	CCLE	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328S	HCC-44	lung	COSMIC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328Q	TCGA-FS-A1ZD	SKCM	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328Q	DO37627	SKCM	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.R334C	TCGA-ZF-AA5H	BLCA	TCGA	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1389
p.R334C	DO219101	BLCA	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1389
p.A333S	DO229029	LICA	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1667
p.D332G	DO229041	LICA	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.1944
p.G336V	DO229009	LICA	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.0833
p.P325L	DO222595	MELA	ICGC	PPSY	ITCH	324:327	Mutation altering degron motif	0.7582
p.S322L	DO36556	READ	ICGC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.2778
p.P328L	SIDM01210	Glioblastoma	GDSC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328L	ACH-000479	Brain Cancer	CCLE	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328L	ACH-002259	Brain Cancer	CCLE	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056
p.P328L	KNS-81-FD	central nervous system	COSMIC	PPSY	ITCH	324:327	Mutation rewiring degron network	0.3056

Kaplan plot for INPP5A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INPP5A

UniProt ID: Q14642

Entrez ID: 3632

Protein name: Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INPP5A in