DegronMD - Q14722(KCNAB1)

FUNCTION: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63143, ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:8938711, ECO:0000269|PubMed:9763623, ECO:0000305}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R408H	TCGA-2W-A8YY	CESC	TCGA	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.1111
p.R408H	TCGA-AZ-6601	COAD	TCGA	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.1111
p.R408H	TCGA-UY-A78K	BLCA	TCGA	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.1111
p.R408H	TCGA-VQ-A8PX	STAD	TCGA	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.1111
p.R408H	SIDM02044	Colorectal Carcinoma	GDSC	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.1111
p.K410N	TCGA-DX-A6YS	SARC	TCGA	DYR	CBL_MET	416:418	Mutation substituting flanking lysine	0.2778
p.D416H	TCGA-IG-A51D	ESCA	TCGA	DYR	CBL_MET	416:418	Mutation altering degron motif	0.7688
p.S413T	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.25
p.S413T	NCI-H1869	lung	COSMIC	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.25
p.R408C	SIDM00118	Colorectal Carcinoma	GDSC	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.1111
p.R408C	HCC2998	large intestine	COSMIC	DYR	CBL_MET	416:418	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNAB1

UniProt ID: Q14722

Entrez ID: 7881

Protein name: Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNAB1 in