DegronMD - Q14839(CHD4)

FUNCTION: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.

GO - Biological processes (BP): chromatin remodeling [GO:0006338]; histone deacetylation [GO:0016575]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell fate specification [GO:00... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; histone deacetylase binding [GO:0042826]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:006... View more >>

GO - Cellular component (CC): centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
ERNILSRLA	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Chromodomain-helicase-DNA-binding protein 4	1889:1897	More..
PKTPTPS	DEG_SCF_FBW7_1	FBXW7	Chromodomain-helicase-DNA-binding protein 4	1538:1544	More..
GSDYTPGK	DEG_SCF_SKP2-CKS1_1	SKP2,CSK1	Chromodomain-helicase-DNA-binding protein 4	107:114	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1897L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.8428
p.P1541H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7694
p.P1541H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7694
p.P1541L	TCGA-DA-A1I7	SKCM	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7582
p.P112L	TCGA-NC-A5HN	LUSC	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation altering degron motif	0.7582
p.Q1894H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7582
p.G1542R	SNU-175	large intestine	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7568
p.G1540V	DO26743	LUSC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7532
p.P1541A	TCGA-G2-A2EJ	BLCA	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7503
p.R1888L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation blocking phosphorylation signal	0.75
p.K1537M	CHP-134	autonomic ganglia	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation blocking phosphorylation signal	0.75
p.Q1888H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation blocking phosphorylation signal	0.75
p.R1895L	SIDM00476	Ovarian Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7316
p.R1895L	ACH-001373	Ovarian Cancer	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7316
p.R1895L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7316
p.P105L	DO52025	LUSC	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation blocking phosphorylation signal	0.7222
p.A1891T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7139
p.A1890T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7139
p.A1893T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7139
p.S1896T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7116

Showing 1 to 20 of 90 entries

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No resistance data available for this Degron.

Kaplan plot for CHD4 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD4

UniProt ID: Q14839

Entrez ID: 1108

Protein name: Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for CHD4 in