DegronMD - Q14839(CHD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E106G	TCGA-17-Z023	LUAD	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.3056
p.G1547V	TCGA-37-3789	LUSC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.25
p.K1539E	TCGA-66-2777	LUSC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.591
p.P1903S	TCGA-A5-A0G2	UCEC	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1667
p.P1879A	TCGA-AA-3815	COAD	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.0556
p.D109N	TCGA-B5-A11E	UCEC	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation altering degron motif	0.6932
p.P1533L	TCGA-BA-4074	HNSC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.E1902K	TCGA-BH-A1FE	BRCA	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1944
p.A1882V	TCGA-CK-6746	COAD	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1389
p.M1530I	TCGA-D3-A8GL	SKCM	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1111
p.R102C	TCGA-D8-A1XK	BRCA	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.1944
p.P1541L	TCGA-DA-A1I7	SKCM	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7582
p.S1535L	TCGA-DD-A4NR	LIHC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation blocking phosphorylation signal	0.6944
p.P1879S	TCGA-FR-A8YC	SKCM	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.0556
p.P1541A	TCGA-G2-A2EJ	BLCA	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7503
p.P1543L	TCGA-HU-A4GC	STAD	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.6471
p.P1533T	TCGA-IB-7651	PAAD	TCGA	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.Y110C	TCGA-KK-A8I6	PRAD	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation altering degron motif	0.7087
p.P112L	TCGA-NC-A5HN	LUSC	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation altering degron motif	0.7582
p.S108N	TCGA-XF-AAMG	BLCA	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation altering degron motif	0.7069
p.D104Y	TCGA-XF-AAMG	BLCA	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.25
p.S101N	DO219049	BLCA	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.1667
p.D97Y	DO219049	BLCA	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.0556
p.P1534A	DO554	BLCA	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.2222
p.E1895K	DO4830	BRCA	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7022
p.V1550I	DO17492	KIRC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1667
p.Q1904K	DO229006	LICA	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation blocking phosphorylation signal	0.5833
p.S1528L	DO44923	LIHC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation blocking ubiquitination signal	0.5
p.G1540V	DO26743	LUSC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7532
p.K1532E	DO27516	LUSC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1667
p.P105L	DO52025	LUSC	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation blocking phosphorylation signal	0.7222
p.Y103C	DO219317	PRAD	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation blocking phosphorylation signal	0.6667
p.S123F	DO50281	SKCM	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation substituting flanking lysine	0.1944
p.S123F	DO219482	SKCM	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation substituting flanking lysine	0.1944
p.P1534L	DO37951	SKCM	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.2222
p.N1884D	DO38404	STAD	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1944
p.P1536L	DO47797	STAD	ICGC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.2778
p.D102N	DO41644	UCEC	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.1944
p.P1896S	DO41235	UCEC	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.6752
p.T1549M	SIDM02049	Pancreatic Carcinoma	GDSC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation blocking phosphorylation signal	0.6389
p.G1534R	SIDM00216	Colorectal Carcinoma	GDSC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.2222
p.G1534R	SNU-175	large intestine	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.2222
p.S1894T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.6005
p.S1894T	ACH-000809	Esophageal Cancer	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.6005
p.S1894T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.6005
p.K1529M	SIDM00285	Neuroblastoma	GDSC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation substituting flanking lysine	0.1944
p.K1529M	CHP-134	autonomic ganglia	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation substituting flanking lysine	0.1944
p.Q1886H	SIDM00683	Prostate Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.25
p.Q1886H	ACH-000977	lymph node	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.25
p.Q1886H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.25
p.R1895L	SIDM00476	Ovarian Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7316
p.R1895L	ACH-001373	Ovarian Cancer	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7316
p.R1895L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7316
p.A1900T	SIDM00217	Colorectal Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.25
p.A1900T	ACH-000999	Colon/Colorectal Cancer	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.25
p.A1900T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.25
p.P1541H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7694
p.P1541H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7694
p.R102H	SIDM00760	Small Cell Lung Carcinoma	GDSC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.1944
p.R102H	NCI-H1963	lung	COSMIC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.1944
p.K1554M	ACH-001338	Neuroblastoma	CCLE	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.0556
p.K1554M	CHP-134	autonomic ganglia	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.0556
p.A1891T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7139
p.R1897L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.8428
p.S1896T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7116
p.A1887T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.2778
p.S1902T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1944
p.R1888L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation blocking phosphorylation signal	0.75
p.R1882L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1389
p.P1549H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation blocking phosphorylation signal	0.6389
p.K1537M	CHP-134	autonomic ganglia	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation blocking phosphorylation signal	0.75
p.A1902T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1944
p.R99H	NCI-H1963	lung	COSMIC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	107:114	Mutation rewiring degron network	0.1111
p.P1533H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.P1528H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation blocking ubiquitination signal	0.5
p.R1903L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1667
p.Q1888H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation blocking phosphorylation signal	0.75
p.Q1879H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.0556
p.R1886L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.25
p.R1885L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.2222
p.A1890T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7139
p.S1884T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1944
p.P1534H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.2222
p.A1880T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.0833
p.S1887T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.2778
p.Q1894H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7582
p.S1885T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.2222
p.G1542R	SNU-175	large intestine	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7568
p.A1893T	SNU-1040	large intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation altering degron motif	0.7139
p.S1881T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	1889:1897	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD4

UniProt ID: Q14839

Entrez ID: 1108

Protein name: Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD4 in