DegronMD - Q14938(NFIX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R277H	TCGA-A5-A0GH	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2222
p.R264Q	TCGA-AD-5900	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.R264Q	TCGA-D3-A2JG	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.R264Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.R264Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.R264W	TCGA-CG-5723	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.P270S	TCGA-GN-A266	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.5641
p.R267Q	DO8514	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.7222
p.R267Q	DO47613	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.7222
p.R267Q	ACH-002256	Leukemia	CCLE	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.7222
p.R267Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.7222
p.R280H	DO23460	LINC	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.5833
p.R280H	DO43634	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.5833
p.P273S	DO37432	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.6752
p.G280E	DO48665	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.5833
p.R267W	DO38376	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.7222
p.P273L	DO42568	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.7582
p.P278L	SIDM00545	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.P278L	Mewo	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.D282N	SIDM00983	Bladder Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.0833
p.D282N	647-V	urinary tract	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.0833
p.R263W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.R263W	ACH-000937	Leukemia	CCLE	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.R263W	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.S275C	ACH-000639	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2778
p.S275C	NCI-H211	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2778
p.P281L	ACH-000987	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1111
p.P281L	Mewo	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1111
p.D274N	647-V	urinary tract	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.75
p.R262W	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.G272R	K-562	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.7568
p.D281N	647-V	urinary tract	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1111
p.P277L	Mewo	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2222
p.R266W	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.25
p.P270L	Mewo	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.6471
p.R263Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667

Kaplan plot for NFIX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFIX

UniProt ID: Q14938

Entrez ID: 4784

Protein name: Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFIX in