PUM3
UniProt ID: Q15397
Entrez ID: 9933
Protein name: Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By ...
FUNCTION: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). {ECO:0000250|UniProtKB:X1WGX5, ECO:0000269|PubMed:21266351, ECO:0000269|PubMed:25512524}.
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GO - Biological processes (BP):
regulation of protein ADP-ribosylation [GO:0010835]; regulation of translation [GO:0006417]...
regulation of protein ADP-ribosylation [GO:0010835]; regulation of translation [GO:0006417]
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GO - Molecular function (MF):
DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]...
DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]
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GO - Cellular component (CC):
chromosome [GO:0005694]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]...
chromosome [GO:0005694]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]
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PUM3
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Kaplan plot for PUM3 in
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*NOTE: the Kaplan plots were collected from OncoLnc