DegronMD - Q15475(SIX1)

GO - Biological processes (BP): aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cochlea morphogenesis [GO:0090103]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; endothelin receptor signaling pathway [GO:0086100]; epithelial cell differentiation [GO:0030855]; facial nerve morphogenesis [GO:0021610]; fungiform papilla morphogenesis [GO:0061197]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesonephric tubule formation [GO:0072172]; metanephric mesenchyme development [GO:0072075]; middle ear morphogenesis [GO:0042474]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell differentiation [GO:0014033]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; olfactory placode formation [GO:0030910]; organ induction [GO:0001759]; otic vesicle development [GO:0071599]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization [GO:0032880]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trigeminal ganglion development [GO:0061551]; ureteric bud development [GO:0001657]; ureter smooth muscle cell differentiation [GO:0072193] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q266H	TCGA-59-2352	OV	TCGA	PLTSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1111
p.Q264R	TCGA-78-7155	LUAD	TCGA	PLTSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.0556
p.L282V	TCGA-CD-8530	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2222
p.G283R	SIDM01175	Other Sarcomas	GDSC	PLTSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1944
p.G283R	SW684	soft tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIX1

UniProt ID: Q15475

Entrez ID: 6495

Protein name: Homeobox protein SIX1 (Sine oculis homeobox homolog 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIX1 in