DegronMD - Q15654(TRIP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T133M	TCGA-06-0882	GBM	TCGA	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2778
p.T133M	DO14013	GBM	ICGC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2778
p.R132L	TCGA-39-5011	LUSC	TCGA	PPAY	ITCH	128:131	Mutation rewiring degron network	0.3056
p.R132L	DO27532	LUSC	ICGC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.3056
p.P140T	TCGA-49-AAR4	LUAD	TCGA	PPAY	ITCH	128:131	Mutation rewiring degron network	0.0833
p.P140T	DO218920	LUAD	ICGC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.0833
p.R120P	TCGA-DD-AACM	LIHC	TCGA	PPAY	ITCH	128:131	Mutation rewiring degron network	0.1111
p.R120P	DO52209	LIHC	ICGC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.1111
p.A122S	DO228948	LICA	ICGC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.1667
p.A122S	DO228978	LICA	ICGC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.1667
p.Q121L	DO229264	THCA	ICGC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.1389
p.S135F	SIDM00664	Pancreatic Carcinoma	GDSC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2222
p.S135F	ACH-000178	Pancreatic Cancer	CCLE	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2222
p.S135F	Hs766T	pancreas	COSMIC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2222
p.S135C	SIDM00846	Cervical Carcinoma	GDSC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2222
p.S135C	ACH-001086	Cervical Cancer	CCLE	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2222
p.S135C	HeLa	cervix	COSMIC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.2222
p.R132C	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.3056
p.R132C	SC-1	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	128:131	Mutation rewiring degron network	0.3056

Kaplan plot for TRIP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIP6

UniProt ID: Q15654

Entrez ID: 7205

Protein name: Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIP6 in