DegronMD - Q15796(SMAD2)

GO - Biological processes (BP): activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; common-partner SMAD protein phosphorylation [GO:0007182]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; endoderm formation [GO:0001706]; gastrulation [GO:0007369]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; mesoderm formation [GO:0001707]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; nodal signaling pathway [GO:0038092]; organ growth [GO:0035265]; pancreas development [GO:0031016]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; primary miRNA processing [GO:0031053]; regulation of binding [GO:0051098]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to cholesterol [GO:0070723]; response to glucose [GO:0009749]; secondary palate development [GO:0062009]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein complex assembly [GO:0007183]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; wound healing [GO:0042060]; zygotic specification of dorsal/ventral axis [GO:0007352] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G230V	TCGA-BF-A1PU	SKCM	TCGA	PPGY	ITCH	222:225	Mutation rewiring degron network	0.1944
p.G230V	DO50278	SKCM	ICGC	PPGY	ITCH	222:225	Mutation rewiring degron network	0.1944
p.T220K	DO229015	LICA	ICGC	PPGY	ITCH	222:225	Mutation blocking phosphorylation signal	0.7222
p.T220M	SIDM00216	Colorectal Carcinoma	GDSC	PPGY	ITCH	222:225	Mutation blocking phosphorylation signal	0.7222
p.T220M	ACH-000989	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	222:225	Mutation blocking phosphorylation signal	0.7222
p.T220M	SNU-175	large intestine	COSMIC	PPGY	ITCH	222:225	Mutation blocking phosphorylation signal	0.7222
p.S233G	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	222:225	Mutation rewiring degron network	0.1111
p.S233G	ACH-000942	Leukemia	CCLE	PPGY	ITCH	222:225	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMAD2

UniProt ID: Q15796

Entrez ID: 4087

Protein name: Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMAD2 in