DegronMD - Q15797(SMAD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S190T	TCGA-22-4613	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.S190T	DO26468	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.D221G	TCGA-75-7031	LUAD	TCGA	PPAY	ITCH	224:227	Mutation rewiring degron network	0.25
p.D221G	DO25545	LUAD	ICGC	PPAY	ITCH	224:227	Mutation rewiring degron network	0.25
p.D232H	TCGA-78-7220	LUAD	TCGA	PPAY	ITCH	224:227	Mutation rewiring degron network	0.1944
p.D232H	DO24409	LUAD	ICGC	PPAY	ITCH	224:227	Mutation rewiring degron network	0.1944
p.T222M	TCGA-D1-A16X	UCEC	TCGA	PPAY	ITCH	224:227	Mutation rewiring degron network	0.2778
p.T222M	DO41799	UCEC	ICGC	PPAY	ITCH	224:227	Mutation rewiring degron network	0.2778
p.G197V	TCGA-D5-6928	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.6421
p.G197V	DO7776	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.6421
p.G197W	TCGA-G7-6797	KIRP	TCGA	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.6714
p.G197W	DO20917	KIRP	ICGC	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.6714
p.G197W	DO229036	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.6714
p.Q236R	TCGA-GV-A3QH	BLCA	TCGA	PPAY	ITCH	224:227	Mutation rewiring degron network	0.0833
p.Q236R	DO464	BLCA	ICGC	PPAY	ITCH	224:227	Mutation rewiring degron network	0.0833
p.T202A	DO227987	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation blocking phosphorylation signal	0.7222
p.D237Y	DO229019	LICA	ICGC	PPAY	ITCH	224:227	Mutation rewiring degron network	0.0556
p.P188T	DO51075	PRAD	ICGC	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.T235A	SIDM00845	Burkitt's Lymphoma	GDSC	PPAY	ITCH	224:227	Mutation rewiring degron network	0.1111
p.A226V	SIDM00565	Oral Cavity Carcinoma	GDSC	PPAY	ITCH	224:227	Mutation altering degron motif	0.5825
p.A226V	ACH-001626	Head and Neck Cancer	CCLE	PPAY	ITCH	224:227	Mutation altering degron motif	0.5825
p.A226V	OSC-20	upper aerodigestive tract	COSMIC	PPAY	ITCH	224:227	Mutation altering degron motif	0.5825
p.S214I	ACH-001991	Primary	CCLE	PPAY	ITCH	224:227	Mutation blocking phosphorylation signal	0.5
p.P207S	ACH-002287	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1389
p.P207S	NCI-H630	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1389

Kaplan plot for SMAD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMAD1

UniProt ID: Q15797

Entrez ID: 4086

Protein name: Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMAD1 in