DegronMD - Q15814(TBCC)

FUNCTION: Tubulin-folding protein; involved in the final step of the tubulin folding pathway. {ECO:0000269|PubMed:11847227}.

GO - Biological processes (BP): post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]

GO - Molecular function (MF): chaperone binding [GO:0051087]; GTPase activity [GO:0003924]; tubulin binding [GO:0015631]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
AASST	DEG_SPOP_SBC_1	SPOP	Tubulin-specific chaperone C	146:150	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T150A	TCGA-FI-A2D5	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7139
p.T150A	DO41331	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7139
p.A147D	DO27779	MALY	ICGC	AASST	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.6682
p.G157D	SIDM00875	Breast Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1389
p.G157D	SIDM00257	Neuroblastoma	GDSC	AASST	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1389
p.G157D	SIDM00760	Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1389
p.P159S	TCGA-KL-8337	KICH	TCGA	AASST	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.P159S	DO220345	KICH	ICGC	AASST	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.P160Q	TCGA-CR-7391	HNSC	TCGA	AASST	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0556
p.P160Q	DO15198	HNSC	ICGC	AASST	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0556

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No resistance data available for this Degron.

Kaplan plot for TBCC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBCC

UniProt ID: Q15814

Entrez ID: 6903

Protein name: Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for TBCC in