DegronMD - Q16549(PCSK7)

PCSK7

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E754Q	TCGA-DK-A6B6	BLCA	TCGA	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0833
p.E754Q	DO48576	BLCA	ICGC	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0833
p.V734M	TCGA-EE-A3AE	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1389
p.V734M	DO37802	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1389
p.E733K	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.E733K	SIDM01520	Oral Cavity Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.E733K	ACH-000503	Head and Neck Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.E733K	ACH-000860	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.E733K	NCI-H358	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.T743N	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	741:745	Mutation altering degron motif	0.7055

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*NOTE: the Kaplan plots were collected from OncoLnc