DegronMD - Q16655(MLANA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E105D	TCGA-77-6842	LUSC	TCGA	PPAY	ITCH	101:104	Mutation rewiring degron network	0.3056
p.E105D	TCGA-77-6842	LUSC	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1111
p.E105D	DO229041	LICA	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.3056
p.E105D	DO229041	LICA	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1111
p.E105D	DO27413	LUSC	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.3056
p.E105D	DO27413	LUSC	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1111
p.K91E	TCGA-B5-A3FA	UCEC	TCGA	PPAY	ITCH	101:104	Mutation substituting flanking lysine	0.1667
p.K91E	DO52402	UCEC	ICGC	PPAY	ITCH	101:104	Mutation substituting flanking lysine	0.1667
p.P113Q	TCGA-D3-A2JD	SKCM	TCGA	PPPY	ITCH	113:116	Mutation altering degron motif	0.7035
p.P113Q	DO37543	SKCM	ICGC	PPPY	ITCH	113:116	Mutation altering degron motif	0.7035
p.P98H	TCGA-D3-A2JL	SKCM	TCGA	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.P98H	DO47278	SKCM	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.K91T	TCGA-DD-AAVP	LIHC	TCGA	PPAY	ITCH	101:104	Mutation substituting flanking lysine	0.1667
p.K91T	DO52275	LIHC	ICGC	PPAY	ITCH	101:104	Mutation substituting flanking lysine	0.1667
p.E105Q	TCGA-G2-A3VY	BLCA	TCGA	PPAY	ITCH	101:104	Mutation rewiring degron network	0.3056
p.E105Q	TCGA-G2-A3VY	BLCA	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1111
p.E105Q	DO590	BLCA	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.3056
p.E105Q	DO590	BLCA	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1111
p.P98S	TCGA-W3-AA1Q	SKCM	TCGA	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.P98S	DO219487	SKCM	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.A100V	DO232761	PBCA	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.3056
p.L107H	SIDM00663	Melanoma	GDSC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.L107H	SIDM00663	Melanoma	GDSC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.L107H	ACH-000814	Skin Cancer	CCLE	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.L107H	ACH-000814	Skin Cancer	CCLE	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.L107H	Hs939-T	skin	COSMIC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.L107H	Hs939-T	skin	COSMIC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.A109V	SIDM01088	Endometrial Carcinoma	GDSC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.1944
p.A109V	SIDM01088	Endometrial Carcinoma	GDSC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.A109V	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPAY	ITCH	101:104	Mutation rewiring degron network	0.1944
p.A109V	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.A109V	RL95-2	endometrium	COSMIC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.1944
p.A109V	RL95-2	endometrium	COSMIC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.N99S	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.2778
p.P98L	SIDM00604	Oral Cavity Carcinoma	GDSC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25

Kaplan plot for MLANA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLANA

UniProt ID: Q16655

Entrez ID: 2315

Protein name: Melanoma antigen recognized by T-cells 1 (MART-1) (Antigen LB39-AA) (Antigen SK29-AA) (Protein Melan-A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLANA in