DegronMD - Q16836(HADH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S19L	TCGA-C5-A1BM	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S19L	DO49007	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S19L	SIDM00240	Cervical Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S19L	ACH-001515	Cervical Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S19L	ACH-002180	Cervical Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S19L	OMC-1	cervix	COSMIC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S15L	TCGA-GD-A3OP	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7667
p.S15L	DO761	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7667
p.S21W	TCGA-MV-A51V	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.S21W	DO474	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.C13W	DO51222	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7
p.L6V	DO222652	BTCA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1667
p.R10H	DO233652	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.2778
p.G7R	DO233941	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.G7V	DO229034	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.P12S	DO220890	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.6752
p.P12S	DO227531	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.6752
p.P12S	DO37432	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.6752
p.G20E	DO220906	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.2222
p.R3K	DO222599	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.5278
p.P11S	DO222837	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.3056
p.R3S	DO46331	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.5278
p.D13N	DO42713	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.6932
p.V8A	ACH-000947	Ovarian Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	12:16	Mutation substituting flanking lysine	0.3333

Kaplan plot for HADH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HADH

UniProt ID: Q16836

Entrez ID: 3033

Protein name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HADH in