DegronMD - Q17RH7(TPRXL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S208R	TCGA-3B-A9HI	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7427
p.S208R	DO219926	SARC	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7427
p.S208R	ACH-001610	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7427
p.P69S	TCGA-A7-A6VX	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.P69S	DO50019	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.S88P	TCGA-AJ-A2QO	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.3056
p.S88P	TCGA-AJ-A2QO	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.S88P	DO42177	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.3056
p.S88P	DO42177	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.T89S	TCGA-AJ-A2QO	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.2778
p.T89S	TCGA-AJ-A2QO	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.T89S	DO42177	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.2778
p.T89S	DO42177	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R203H	TCGA-DI-A2QY	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.8244
p.R203H	DO42031	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.8244
p.S209T	DO50463	BOCA	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6005
p.S209T	DO230319	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6005
p.S209T	DO223148	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6005
p.S209T	DO228819	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6005
p.S209T	DO224610	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6005
p.S209T	DO228858	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6005
p.S209T	DO232927	PEME	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6005
p.P207S	DO50463	BOCA	ICGC	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.P207S	DO223151	ESCA	ICGC	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.P207S	DO228819	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.P207S	DO23212	LINC	ICGC	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.P207S	DO232927	PEME	ICGC	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.H78P	DO222439	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1944
p.P69H	DO222990	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.P69H	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.P69H	DO229013	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.P69H	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.P69H	DO229003	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.P69H	DO229005	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.P69H	DO230937	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.S223N	DO222973	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7069
p.C231S	DO52700	CLLE	ICGC	PSSSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.7541
p.C231S	DO232899	PEME	ICGC	PSSSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.7541
p.P74R	DO223408	CLLE	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.0833
p.P74R	DO228610	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.0833
p.S212P	DO223151	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.6752
p.S219T	DO228769	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO233682	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO229354	LAML	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO227496	LAML	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO227513	LAML	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO224548	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO224566	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO224584	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO224610	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO224624	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO231246	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO231346	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO231350	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S219T	DO231319	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6005
p.S229N	DO233709	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.5958
p.S166N	DO15414	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1111
p.S166N	DO15414	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.G176S	DO228833	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.P83H	DO50767	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation altering degron motif	0.7694
p.S84T	DO23086	LINC	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation altering degron motif	0.6005
p.P83S	DO23086	LINC	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation altering degron motif	0.6752
p.S169N	DO23310	LINC	ICGC	PSSSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.5958
p.S121T	DO228584	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7116
p.S213N	DO220886	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1667
p.S213N	DO220886	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.3056
p.S213N	DO220886	MELA	ICGC	PSTSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.S213N	DO220886	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.0556
p.S181R	DO49197	PACA	ICGC	PSSSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0833
p.S132C	DO227650	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7541
p.S157T	DO227750	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7116
p.P74H	DO231350	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.0833
p.S224T	ACH-000036	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.6005
p.S190G	ACH-000091	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.S190G	ACH-000481	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.S190G	ACH-001193	Bone Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.S190G	ACH-001547	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.S190G	ACH-001559	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.S182R	ACH-000238	Head and Neck Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0556
p.S223I	ACH-000463	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7341
p.G237C	ACH-000563	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.0556
p.G237C	ACH-000563	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.1944
p.S108T	ACH-000768	Breast Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.0556
p.S129N	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7069
p.S132T	ACH-000957	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6005
p.S132T	ACH-001955	Bone Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6005
p.G176D	ACH-001075	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.G176D	ACH-001834	Bile Duct Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.S139P	ACH-001398	Kidney Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7863
p.T89I	ACH-001532	Rhabdoid	CCLE	PSSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.2778
p.T89I	ACH-001532	Rhabdoid	CCLE	PSSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPRXL

UniProt ID: Q17RH7

Entrez ID:

Protein name: Putative protein TPRXL

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPRXL in