DegronMD - Q2KHR3(QSER1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1194N	TCGA-06-1802	GBM	TCGA	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation substituting flanking lysine	0.2778
p.K1194N	DO12100	GBM	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation substituting flanking lysine	0.2778
p.A267V	TCGA-06-5416	GBM	TCGA	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.A267V	DO10880	GBM	ICGC	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.A267V	SIDM00534	Colorectal Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.A267V	ACH-000986	Colon/Colorectal Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.A267V	HT-115	large intestine	COSMIC	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.N1210S	TCGA-19-5956	GBM	TCGA	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.1944
p.N1210S	DO13863	GBM	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.1944
p.V366I	TCGA-39-5034	LUSC	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.2222
p.V366I	DO26854	LUSC	ICGC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.2222
p.S1056I	TCGA-46-3769	LUSC	TCGA	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0833
p.S1056I	DO26590	LUSC	ICGC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0833
p.S1245R	TCGA-85-7710	LUSC	TCGA	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation rewiring degron network	0.3056
p.S1245R	DO26826	LUSC	ICGC	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation rewiring degron network	0.3056
p.P1191L	TCGA-95-A4VN	LUAD	TCGA	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.0833
p.P1191L	TCGA-95-A4VN	LUAD	TCGA	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.P1191L	DO51199	LUAD	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.0833
p.P1191L	DO51199	LUAD	ICGC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.F378C	TCGA-AA-3510	COAD	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1944
p.F378C	DO7783	COAD	ICGC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1944
p.F378L	TCGA-AG-A002	READ	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1944
p.S140Y	TCGA-AX-A06F	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.S140Y	DO41752	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.R1101H	TCGA-AX-A1C9	UCEC	TCGA	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.0556
p.R1101H	DO43098	UCEC	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.0556
p.Y166C	TCGA-B5-A11E	UCEC	TCGA	AYSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.5976
p.Y166C	DO41644	UCEC	ICGC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.5976
p.S379Y	TCGA-BR-8680	STAD	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1667
p.S379Y	DO47769	STAD	ICGC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1667
p.S159F	TCGA-BR-A4QL	STAD	TCGA	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.S159F	DO38723	STAD	ICGC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.S159F	SIDM01000	Melanoma	GDSC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.S159F	ACH-000304	Skin Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.S159F	ACH-000726	Esophageal Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.S159F	WM-115	skin	COSMIC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.I1454S	TCGA-BS-A0UV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1389
p.I1454S	DO42793	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1389
p.M1036V	TCGA-BS-A0V8	UCEC	TCGA	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.25
p.M1036V	DO42240	UCEC	ICGC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.25
p.S379F	TCGA-BT-A2LA	BLCA	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1667
p.S379F	DO561	BLCA	ICGC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1667
p.V1204M	TCGA-C8-A12K	BRCA	TCGA	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation altering degron motif	0.6097
p.V1204M	DO1258	BRCA	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation altering degron motif	0.6097
p.I1109M	TCGA-CA-6717	COAD	TCGA	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.2778
p.I1109M	DO8264	COAD	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.2778
p.S382A	TCGA-CG-4436	STAD	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.0833
p.S382A	DO38320	STAD	ICGC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.0833
p.L99F	TCGA-CJ-6028	KIRC	TCGA	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.1944
p.L99F	DO16803	KIRC	ICGC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.1944
p.P1212L	TCGA-CV-7568	HNSC	TCGA	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.1389
p.P1212L	DO14160	HNSC	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.1389
p.P1273Q	TCGA-D3-A2JC	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.3056
p.P1273Q	TCGA-D3-A2JC	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1111
p.P1273Q	TCGA-D3-A2JP	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.3056
p.P1273Q	TCGA-D3-A2JP	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1111
p.P1273Q	DO47407	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.3056
p.P1273Q	DO47407	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1111
p.P1273Q	DO47578	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.3056
p.P1273Q	DO47578	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1111
p.S94G	TCGA-D3-A8GQ	SKCM	TCGA	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.S94G	DO51246	SKCM	ICGC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.S1032C	TCGA-D7-8573	STAD	TCGA	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation blocking phosphorylation signal	0.5833
p.S1032C	DO48001	STAD	ICGC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation blocking phosphorylation signal	0.5833
p.H95D	TCGA-D8-A1JA	BRCA	TCGA	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0833
p.H95D	DO2819	BRCA	ICGC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0833
p.P1470S	TCGA-DA-A1HV	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1944
p.P1470S	DO37659	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1944
p.A1042T	TCGA-DF-A2KU	UCEC	TCGA	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.6028
p.A1042T	DO223286	UCEC	ICGC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.6028
p.E116Q	TCGA-DV-5565	KIRC	TCGA	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.2222
p.E116Q	DO19693	KIRC	ICGC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.2222
p.G380V	TCGA-E7-A3Y1	BLCA	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.G380V	TCGA-G3-AAV6	LIHC	TCGA	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.G380V	DO528	BLCA	ICGC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.G380V	DO52299	LIHC	ICGC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.1389
p.A165V	TCGA-EE-A2MC	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.5825
p.A165V	DO222426	MELA	ICGC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.5825
p.A165V	DO37559	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.5825
p.S1117F	TCGA-EE-A2MR	SKCM	TCGA	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation altering degron motif	0.6871
p.S1117F	DO37819	SKCM	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation altering degron motif	0.6871
p.Q1458R	TCGA-MX-A5UJ	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.25
p.Q1458R	DO48547	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.25
p.L1043F	TCGA-ZG-A9N3	PRAD	TCGA	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.6981
p.L1043F	DO219446	PRAD	ICGC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.6981
p.T1248A	DO225346	BRCA	ICGC	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation altering degron motif	0.825
p.E1294D	DO224602	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.0833
p.E1294D	DO1012	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.0833
p.S167I	DO222762	COCA	ICGC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7341
p.G1209S	DO234230	ESAD	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.2222
p.G1209S	DO234230	ESAD	ICGC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.0556
p.S270L	DO233796	GACA	ICGC	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2222
p.L516F	DO229018	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.S173I	DO229045	LICA	ICGC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.P1112S	DO45229	LIRI	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation altering degron motif	0.5641
p.P1112S	SIDM01047	Chronic Myelogenous Leukemia	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation altering degron motif	0.5641
p.P1112S	ACH-000295	Leukemia	CCLE	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation altering degron motif	0.5641
p.P1112S	EM-2	haematopoietic and lymphoid tissue	COSMIC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation altering degron motif	0.5641
p.T285R	DO224544	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.T285R	DO224544	LUSC	ICGC	PLTST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.T285R	DO231014	LUSC	ICGC	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.T285R	DO231014	LUSC	ICGC	PLTST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.E116K	DO220891	MELA	ICGC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.2222
p.S276T	DO222595	MELA	ICGC	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.6005
p.P302S	DO222837	MELA	ICGC	PLTST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.0556
p.T1201I	DO35242	PACA	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation altering degron motif	0.7078
p.G1029S	DO52146	PAEN	ICGC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0556
p.S509A	DO232761	PBCA	ICGC	VQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.S1197C	DO229472	PRAD	ICGC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation altering degron motif	0.7541
p.S1257Y	SIDM00216	Colorectal Carcinoma	GDSC	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation blocking phosphorylation signal	0.6389
p.S1257Y	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation blocking phosphorylation signal	0.6389
p.S1257Y	SNU-175	large intestine	COSMIC	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation blocking phosphorylation signal	0.6389
p.V1034M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1944
p.V1034M	ACH-000920	Leukemia	CCLE	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1944
p.V1034M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1944
p.V109I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01196	Hepatocellular Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00574	Glioblastoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00580	Acute Myeloid Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00996	Thyroid Gland Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00603	Head and Neck Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01693	B-Lymphoblastic Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01464	Pancreatic Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00497	Colorectal Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.D1123N	SIDM00866	Breast Carcinoma	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.1944
p.D1123N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.1944
p.D1123N	SIDM00868	Non-Cancerous	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.1944
p.D1123N	ACH-000374	Breast Cancer	CCLE	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.1944
p.D1123N	ACH-000766	Lung Cancer	CCLE	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.1944
p.T1453I	SIDM00608	Plasma Cell Myeloma	GDSC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1111
p.T1453I	ACH-000714	Myeloma	CCLE	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1111
p.T1453I	KMS-11	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1111
p.V122A	SIDM00845	Burkitt's Lymphoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.V122A	SIDM00845	Burkitt's Lymphoma	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.V122A	SIDM00035	Thyroid Gland Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.V122A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.V122A	SIDM00461	Acute Myeloid Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.V122A	SIDM00461	Acute Myeloid Leukemia	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.V122A	SIDM01519	Head and Neck Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.V122A	SIDM01519	Head and Neck Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.V122A	ACH-000786	Lymphoma	CCLE	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.V122A	ACH-000786	Lymphoma	CCLE	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.V122A	ACH-000992	Head and Neck Cancer	CCLE	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.V122A	ACH-000992	Head and Neck Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.V122A	Daudi	haematopoietic and lymphoid tissue	COSMIC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation rewiring degron network	0.0556
p.V122A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.I127V	SIDM00845	Burkitt's Lymphoma	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.I127V	SIDM00461	Acute Myeloid Leukemia	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.I127V	SIDM01519	Head and Neck Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.I127V	ACH-000786	Lymphoma	CCLE	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.I127V	ACH-000992	Head and Neck Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.I127V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.A155T	SIDM00845	Burkitt's Lymphoma	GDSC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.A155T	Daudi	haematopoietic and lymphoid tissue	COSMIC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.S159A	SIDM00845	Burkitt's Lymphoma	GDSC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.K365R	SIDM00845	Burkitt's Lymphoma	GDSC	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	SIDM00035	Thyroid Gland Carcinoma	GDSC	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	SIDM00461	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	SIDM01519	Head and Neck Carcinoma	GDSC	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	ACH-000786	Lymphoma	CCLE	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	ACH-000992	Head and Neck Cancer	CCLE	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	ACH-001067	Brain Cancer	CCLE	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.K365R	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	370:373	Mutation substituting flanking lysine	0.3056
p.P371S	SIDM00845	Burkitt's Lymphoma	GDSC	PPLY	ITCH	370:373	Mutation altering degron motif	0.6752
p.P371S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PPLY	ITCH	370:373	Mutation altering degron motif	0.6752
p.P371S	SIDM00461	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	370:373	Mutation altering degron motif	0.6752
p.P371S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	370:373	Mutation altering degron motif	0.6752
p.P371S	SIDM01519	Head and Neck Carcinoma	GDSC	PPLY	ITCH	370:373	Mutation altering degron motif	0.6752
p.P371S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	370:373	Mutation altering degron motif	0.6752
p.A1269T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.6028
p.A1269T	ACH-002256	Leukemia	CCLE	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.6028
p.A1269T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.6028
p.T1286A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.3056
p.T1286A	ACH-002256	Leukemia	CCLE	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.3056
p.T1286A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.3056
p.P288T	SIDM00255	Neuroblastoma	GDSC	PLTST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7031
p.P288T	ACH-002282	Neuroblastoma	CCLE	PLTST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7031
p.P288T	NB17	autonomic ganglia	COSMIC	PLTST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7031
p.S1056G	SIDM00690	Head and Neck Carcinoma	GDSC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0833
p.P1461Q	SIDM00562	Breast Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7035
p.P1461Q	ACH-002163	Breast Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7035
p.P1461Q	MRK-nu-1	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7035
p.A518V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	VQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.A518V	ACH-001738	Leukemia	CCLE	VQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.A518V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.P1189L	SIDM00988	Kidney Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1667
p.P1189L	SIDM01578	Bladder Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1667
p.P1189L	BFTC-909	kidney	COSMIC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1667
p.Y134C	SIDM01608	Endometrial Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.Y134C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.A1042V	SIDM01682	Gastric Carcinoma	GDSC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5825
p.A1042V	ACH-000110	Gastric Cancer	CCLE	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5825
p.H1122R	SIDM01394	Kidney Carcinoma	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.2222
p.T1263A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.1944
p.T1263A	ACH-000942	Leukemia	CCLE	VATTS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.1944
p.S291T	ACH-001538	Bile Duct Cancer	CCLE	PLTST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6005
p.P275L	ACH-001857	Bile Duct Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.6471
p.E1291V	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1667
p.V371A	RKO	large intestine	COSMIC	PPLY	ITCH	370:373	Mutation altering degron motif	0.6936
p.T1214I	KMS-11	haematopoietic and lymphoid tissue	COSMIC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.0833
p.T1047A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.7139
p.T1282S	NCI-H345	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.6005
p.A1030T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0833
p.P527L	SW684	soft tissue	COSMIC	VQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.R377H	TUR	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	370:373	Mutation rewiring degron network	0.2222
p.A279V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PLTST	DEG_SPOP_SBC_1	288:292	Mutation substituting flanking lysine	0.1944
p.P527S	SW684	soft tissue	COSMIC	VQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.E1192K	NCI-H1781	lung	COSMIC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation rewiring degron network	0.1111
p.E1192K	NCI-H1781	lung	COSMIC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.25
p.Q1463L	GOTO	autonomic ganglia	COSMIC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7765
p.T1239A	NCI-H211	lung	COSMIC	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation blocking phosphorylation signal	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

QSER1

UniProt ID: Q2KHR3

Entrez ID: 79832

Protein name: Glutamine and serine-rich protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for QSER1 in