DegronMD - Q2KHR3(QSER1)

FUNCTION: Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}.

GO - Biological processes (BP):

GO - Molecular function (MF):

GO - Cellular component (CC): chromosome [GO:0005694]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1248A	DO225346	BRCA	ICGC	VSTPLTT	DEG_SCF_FBW7_1	1246:1252	Mutation altering degron motif	0.825
p.Q1463L	GOTO	autonomic ganglia	COSMIC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7765
p.S1197C	DO229472	PRAD	ICGC	PSSTT	DEG_SPOP_SBC_1	1195:1199	Mutation altering degron motif	0.7541
p.S167I	DO222762	COCA	ICGC	AYSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7341
p.T1047A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSALALLA	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.7139
p.T1201I	DO35242	PACA	ICGC	PTPLVS	DEG_SCF_FBW7_1	1200:1205	Mutation altering degron motif	0.7078
p.V109I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01196	Hepatocellular Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00574	Glioblastoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00580	Acute Myeloid Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00996	Thyroid Gland Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00603	Head and Neck Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01693	B-Lymphoblastic Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01464	Pancreatic Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.V109I	SIDM00497	Colorectal Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	104:112	Mutation altering degron motif	0.7076
p.P1461Q	SIDM00562	Breast Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7035
p.P1461Q	ACH-002163	Breast Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7035
p.P1461Q	MRK-nu-1	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.7035

Showing 1 to 20 of 214 entries

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Kaplan plot for QSER1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

QSER1

UniProt ID: Q2KHR3

Entrez ID: 79832

Protein name: Glutamine and serine-rich protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for QSER1 in