DegronMD - Q2M243(CCDC27)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A218T	TCGA-06-5416	GBM	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.A218T	TCGA-G4-6628	COAD	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.A218T	DO10132	COAD	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.A218T	DO10880	GBM	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.A218T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.A218T	ACH-000938	Leukemia	CCLE	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.A218T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.A218T	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.R204I	TCGA-AA-A010	COAD	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389
p.S219Y	TCGA-AP-A059	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.S219Y	DO41361	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.S206F	TCGA-EE-A29H	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.6389
p.S206F	DO220851	MELA	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.6389
p.S206F	DO37535	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.6389
p.R201W	TCGA-EO-A3B0	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.R201W	DO219773	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.R201W	ACH-000593	Bladder Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.R204K	TCGA-FW-A3R5	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389
p.R204K	DO37406	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389
p.R201L	DO229022	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.Q207K	DO229257	THCA	ICGC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.P211T	SIDM00803	Kidney Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7031
p.P211T	ACH-000411	Kidney Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7031
p.P211T	769-P	kidney	COSMIC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7031
p.K205E	SIDM00500	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation substituting flanking lysine	0.2778
p.K205E	ACH-000959	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	211:215	Mutation substituting flanking lysine	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC27

UniProt ID: Q2M243

Entrez ID: 148870

Protein name: Coiled-coil domain-containing protein 27

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC27 in