DegronMD - Q38SD2(LRRK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1874N	TCGA-85-7844	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.1389
p.D1874N	TCGA-M7-A721	PRAD	TCGA	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.1389
p.F1871L	TCGA-AP-A1DV	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.2222
p.S1866F	TCGA-FR-A7U9	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation altering degron motif	0.7982
p.E1873G	DO233901	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.1667
p.S1855N	DO52365	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.5556
p.D1871N	DO27136	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.2222
p.D1871N	DO48614	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.2222
p.S1863F	DO48546	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation altering degron motif	0.7982
p.F1868L	DO43186	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.3056
p.S1858N	SIDM00321	Ovarian Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM00496	Thyroid Gland Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM00299	Other Sarcomas	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM00368	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM00316	Glioblastoma	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM01695	Acute Myeloid Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.S1858N	SIDM01464	Pancreatic Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation blocking phosphorylation signal	0.6389
p.E1876K	SIDM00461	Acute Myeloid Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.0833
p.E1876K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	1863:1867	Mutation rewiring degron network	0.0833

Kaplan plot for LRRK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRK1

UniProt ID: Q38SD2

Entrez ID: 79705

Protein name: Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRK1 in