DegronMD - Q3LI81(KRTAP27-1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P175H	TCGA-17-Z022	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.C161R	TCGA-2Y-A9GV	LIHC	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1389
p.C161R	DO219509	LIHC	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1389
p.L176M	TCGA-2Y-A9GX	LIHC	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.L176M	TCGA-B5-A11E	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.L176M	DO219513	LIHC	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.L176M	DO41644	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.L176Q	TCGA-55-8205	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.L176Q	DO48884	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.P175T	TCGA-55-8506	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.P175T	DO45390	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.Q160H	TCGA-64-5781	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1111
p.Q160H	DO23740	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1111
p.S172F	TCGA-AC-A5XS	BRCA	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7982
p.S172F	DO50023	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7982
p.V177A	TCGA-B5-A0JY	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1944
p.V177A	DO43041	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1944
p.E182A	TCGA-DX-AB3C	SARC	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0556
p.E182A	DO220114	SARC	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0556
p.P168A	TCGA-EM-A3O6	THCA	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.6392
p.P168A	DO48115	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.6392
p.S165C	TCGA-G4-6315	COAD	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.S165C	DO9522	COAD	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.V179I	TCGA-HF-7132	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1389
p.V179I	TCGA-NH-A5IV	COAD	TCGA	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1389
p.V179I	DO49095	COAD	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1389
p.V179I	DO38214	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1389
p.Q162H	DO227661	PACA	ICGC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1667
p.Q166H	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.Q166H	ACH-000766	Lung Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.Q166H	NCI-H1648	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.S171R	SIDM01000	Melanoma	GDSC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7427
p.S171R	ACH-000304	Skin Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7427
p.S171R	WM-115	skin	COSMIC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7427
p.P168S	SIDM01561	Melanoma	GDSC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.6752
p.P168S	ACH-000799	Skin Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.6752
p.N167K	SIDM01561	Melanoma	GDSC	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.3056
p.N167K	ACH-000799	Skin Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRTAP27-1

UniProt ID: Q3LI81

Entrez ID: 643812

Protein name: Keratin-associated protein 27-1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRTAP27-1 in