DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
SPATS1
UniProt ID:
Q496A3
Entrez ID:
221409
Protein name:
Spermatogenesis-associated serine-rich protein 1
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
SPATS1
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.S81T
DO50442
ESAD
ICGC
VSSSS
DEG_SPOP_SBC_1
70:74
Mutation rewiring degron network
0.1389
p.P80R
DO232855
NACA
ICGC
VSSSS
DEG_SPOP_SBC_1
70:74
Mutation rewiring degron network
0.1667
p.P80R
ACH-001412
Bladder Cancer
CCLE
VSSSS
DEG_SPOP_SBC_1
70:74
Mutation rewiring degron network
0.1667
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for SPATS1 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc