DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
TTC31
UniProt ID:
Q49AM3
Entrez ID:
64427
Protein name:
Tetratricopeptide repeat protein 31 (TPR repeat protein 31)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
TTC31
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.D197N
DO233696
GACA
ICGC
ASTTS
DEG_SPOP_SBC_1
202:206
Mutation rewiring degron network
0.1944
p.I198V
DO42608
UCEC
ICGC
ASTTS
DEG_SPOP_SBC_1
202:206
Mutation rewiring degron network
0.2222
p.D207H
SIDM00425
Ovarian Carcinoma
GDSC
ASTTS
DEG_SPOP_SBC_1
202:206
Mutation rewiring degron network
0.3056
p.D207H
ACH-000663
Ovarian Cancer
CCLE
ASTTS
DEG_SPOP_SBC_1
202:206
Mutation rewiring degron network
0.3056
p.D207H
OVTOKO
ovary
COSMIC
ASTTS
DEG_SPOP_SBC_1
202:206
Mutation rewiring degron network
0.3056
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for TTC31 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc