KMT5B
UniProt ID: Q4FZB7
Entrez ID: 51111
Protein name: Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of ge...
FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}.
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GO - Biological processes (BP):
chromatin organization [GO:0006325]; DNA repair [GO:0006281]; histone H4-K20 dimethylation [GO:0034772]; histone H4-K20 trimethylation [GO:0034773]; muscle organ development [GO:0007517]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulatio...
chromatin organization [GO:0006325]; DNA repair [GO:0006281]; histone H4-K20 dimethylation [GO:0034772]; histone H4-K20 trimethylation [GO:0034773]; muscle organ development [GO:0007517]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H4-K20 specific) [GO:0042799]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]...
chromatin binding [GO:0003682]; histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H4-K20 specific) [GO:0042799]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]
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GO - Cellular component (CC):
condensed chromosome, centromeric region [GO:0000779]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
condensed chromosome, centromeric region [GO:0000779]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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KMT5B
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Kaplan plot for KMT5B in
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*NOTE: the Kaplan plots were collected from OncoLnc