DegronMD - Q53G44(IFI44L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R186G	TCGA-34-8454	LUSC	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.3056
p.R186G	DO50094	LUSC	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.3056
p.R199C	TCGA-A5-A0GP	UCEC	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.R199C	TCGA-A5-A2K5	UCEC	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.R199C	TCGA-D1-A16X	UCEC	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.R199C	DO41799	UCEC	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.R199C	DO41109	UCEC	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.R199C	DO41379	UCEC	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.R178I	TCGA-B5-A1MR	UCEC	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0833
p.R178I	DO41758	UCEC	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0833
p.R178I	SIDM01611	Endometrial Carcinoma	GDSC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0833
p.R178I	ACH-000996	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0833
p.D193E	TCGA-DD-AAE0	LIHC	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.D193E	DO52253	LIHC	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.A183T	TCGA-HF-A5NB	STAD	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.A183T	DO50127	STAD	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.A183T	SIDM00839	Colorectal Carcinoma	GDSC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.A183T	ACH-000950	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.A183T	LoVo	large intestine	COSMIC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.D193N	TCGA-SC-A6LP	MESO	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2222
p.I185T	TCGA-ZC-AAAF	THYM	TCGA	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.2778
p.L194V	DO233877	GACA	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.1944
p.R180S	DO229031	LICA	ICGC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.1389
p.H177P	SIDM00125	Kidney Carcinoma	GDSC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.H177P	ACH-000649	Kidney Cancer	CCLE	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556
p.H177P	786-0	kidney	COSMIC	DYR	CBL_MET	187:189	Mutation rewiring degron network	0.0556

Kaplan plot for IFI44L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFI44L

UniProt ID: Q53G44

Entrez ID: 10964

Protein name: Interferon-induced protein 44-like

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IFI44L in