DegronMD - Q53H80(AKIRIN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S121C	TCGA-69-7979	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1944
p.S121C	DO23874	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1944
p.S125L	TCGA-C5-A1M6	CESC	TCGA	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation blocking phosphorylation signal	0.75
p.S125L	DO48985	CESC	ICGC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation blocking phosphorylation signal	0.75
p.L119I	TCGA-EO-A3B0	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1389
p.L119I	DO219773	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1389
p.G127W	TCGA-GN-A26D	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6714
p.G127W	DO37480	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6714
p.E139K	DO224580	LAML	ICGC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833
p.A131V	DO50738	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.3056
p.A132T	SIDM00845	Burkitt's Lymphoma	GDSC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2778
p.A132T	SIDM01519	Head and Neck Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2778
p.P123R	SIDM01128	Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.25
p.P123R	ACH-000767	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.25
p.P123R	NCI-H526	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons