DegronMD - Q53SF7(COBLL1)

GO - Biological processes (BP):

GO - Molecular function (MF): actin monomer binding [GO:0003785]; cadherin binding [GO:0045296]

GO - Cellular component (CC): extracellular exosome [GO:0070062]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
RRAPLPPMP	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Cordon-bleu protein-like 1	293:301	More..
EKENK	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	Cordon-bleu protein-like 1	234:238	More..
DKENN	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	Cordon-bleu protein-like 1	1040:1044	More..
PYSSS	DEG_SPOP_SBC_1	SPOP	Cordon-bleu protein-like 1	979:983	More..
LIIHSE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Cordon-bleu protein-like 1	663:668	More..

Showing 1 to 5 of 5 entries

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R294W	TCGA-06-0122	GBM	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.R294W	TCGA-FI-A2D5	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.R294W	DO12514	GBM	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.R294W	DO41331	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.R1041H	TCGA-BR-4184	STAD	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	DO222427	BTCA	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	DO228138	PBCA	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	DO38328	STAD	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	ACH-000048	Ovarian Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	TOV-112D	ovary	COSMIC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R979T	SIDM00615	Hepatocellular Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7876
p.R979T	JHH-6	liver	COSMIC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7876
p.A982D	TCGA-AP-A059	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7793
p.A980D	TCGA-DX-A6YS	SARC	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7793
p.A980D	DO220005	SARC	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7793
p.D236V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.7785
p.D236V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.7785
p.S1044L	TCGA-XF-AAMG	BLCA	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7667
p.Q979H	TCGA-44-A479	LUAD	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7582
p.Q979H	DO23633	LUAD	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7582

Showing 1 to 20 of 147 entries

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No resistance data available for this Degron.

Kaplan plot for COBLL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COBLL1

UniProt ID: Q53SF7

Entrez ID: 22837

Protein name: Cordon-bleu protein-like 1

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for COBLL1 in