DegronMD - Q53SF7(COBLL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R294W	TCGA-06-0122	GBM	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.R294W	TCGA-FI-A2D5	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.R294W	DO12514	GBM	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.R294W	DO41331	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.8634
p.N228H	TCGA-19-5956	GBM	TCGA	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1667
p.N228H	DO13863	GBM	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1667
p.S1038N	TCGA-24-2281	OV	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.S1038N	DO32459	OV	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.Q979H	TCGA-44-A479	LUAD	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7582
p.Q979H	DO23633	LUAD	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7582
p.E1043K	TCGA-AJ-A3EK	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7022
p.E1043K	TCGA-FI-A2D5	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7022
p.E1043K	DO41584	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7022
p.E1043K	DO41331	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7022
p.Q1035H	TCGA-AP-A051	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1944
p.Q1035H	TCGA-XK-AAIW	PRAD	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1944
p.Q1035H	DO51407	PRAD	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1944
p.Q1035H	DO42673	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1944
p.P298L	TCGA-AP-A056	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6471
p.P298L	DO43971	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6471
p.A982D	TCGA-AP-A059	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7793
p.S985P	TCGA-AP-A0LM	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.2778
p.S985P	DO43306	UCEC	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.2778
p.P299L	TCGA-AP-A0LM	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6471
p.P299L	DO222843	MELA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6471
p.P299L	DO43306	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6471
p.D309G	TCGA-B5-A11E	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1111
p.D309G	DO41644	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1111
p.S1038I	TCGA-BH-A0DK	BRCA	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.S1038I	DO1305	BRCA	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.R1041H	TCGA-BR-4184	STAD	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	DO222427	BTCA	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	DO228138	PBCA	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	DO38328	STAD	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	ACH-000048	Ovarian Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.R1041H	TOV-112D	ovary	COSMIC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.8244
p.D657Y	TCGA-BR-8680	STAD	TCGA	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1667
p.D657Y	DO47769	STAD	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1667
p.E234D	TCGA-BS-A0UF	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.5647
p.E234D	DO41488	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.5647
p.A311E	TCGA-DU-6402	LGG	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0556
p.A311E	DO22264	LGG	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0556
p.I231V	TCGA-DU-7294	LGG	TCGA	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.25
p.I231V	DO22333	LGG	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.25
p.A980D	TCGA-DX-A6YS	SARC	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7793
p.A980D	DO220005	SARC	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7793
p.P991L	TCGA-EE-A182	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1111
p.P991L	DO37814	SKCM	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1111
p.P988S	TCGA-EE-A2MD	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1944
p.P988S	TCGA-EE-A2MI	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1944
p.G978D	TCGA-EE-A3J5	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.3056
p.G978D	DO47331	SKCM	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.3056
p.K235T	TCGA-EO-A22R	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.7306
p.K235T	DO42713	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.7306
p.G978S	TCGA-F1-6874	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.3056
p.G978S	DO38201	STAD	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.3056
p.A1049S	TCGA-HT-7686	LGG	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1944
p.A1049S	DO22716	LGG	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1944
p.R246C	TCGA-LT-A5Z6	BLCA	TCGA	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1111
p.R246C	DO44029	BLCA	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1111
p.R246C	DO233784	GACA	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1111
p.P299S	TCGA-W3-A825	SKCM	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5641
p.P299S	DO51272	SKCM	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5641
p.P307S	TCGA-W3-AA1R	SKCM	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1667
p.P307S	DO51275	SKCM	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1667
p.S1044L	TCGA-XF-AAMG	BLCA	TCGA	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7667
p.P301S	TCGA-ZF-AA4W	BLCA	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5641
p.P301S	DO219089	BLCA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5641
p.D1040H	DO219015	BLCA	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.6577
p.D1040H	DO51597	CESC	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.6577
p.D973N	DO50544	BOCA	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1667
p.F240V	DO233955	BPLL	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.2778
p.V673L	DO225209	BRCA	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1944
p.I225V	DO225120	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.0833
p.I225V	DO227903	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.0833
p.P979S	DO227987	COCA	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.6752
p.R978Q	DO222798	COCA	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.3056
p.K972T	DO222884	COCA	ICGC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation substituting flanking lysine	0.25
p.D675Y	DO222884	COCA	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1389
p.D675Y	DO42312	UCEC	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1389
p.V306A	DO228536	GACA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1944
p.V673I	DO49767	KIRP	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1944
p.V673I	DO38887	STAD	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1944
p.D1032E	DO229027	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1111
p.D245E	DO229035	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1389
p.P286T	DO23394	LINC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.Q670R	DO50850	LIRI	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.2778
p.F1030S	DO228853	MALY	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.L310F	DO220885	MELA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0833
p.Q308P	DO219881	SKCA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.E1042K	DO37531	SKCM	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7022
p.N1043Y	DO51235	SKCM	ICGC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7059
p.D669Y	DO41199	UCEC	ICGC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.3056
p.S1030F	SIDM00586	Hepatocellular Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM00057	Neuroblastoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM00552	Rhabdomyosarcoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM00273	Glioblastoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM01695	Acute Myeloid Leukemia	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM01612	Endometrial Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM00165	Other Solid Cancers	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM01691	Chronic Myelogenous Leukemia	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.S1030F	SIDM01588	Endometrial Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0556
p.K1038N	SIDM00455	Pancreatic Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.K1038N	SIDM01188	Pancreatic Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.K1038N	SIDM01101	Neuroblastoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.K1038N	SIDM00182	Head and Neck Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.R979T	SIDM00615	Hepatocellular Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7876
p.R979T	JHH-6	liver	COSMIC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.7876
p.H239R	SIDM00659	Glioblastoma	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.3056
p.H239R	SIDM00695	Melanoma	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.3056
p.H239R	M059J	central nervous system	COSMIC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.3056
p.H239R	HT-144	skin	COSMIC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.3056
p.D236V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.7785
p.D236V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation altering degron motif	0.7785
p.S987P	SIDM00315	Glioblastoma	GDSC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.2222
p.S987P	YKG-1	central nervous system	COSMIC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.2222
p.I229V	SIDM00417	Plasma Cell Myeloma	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1944
p.I229V	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.1944
p.P667A	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation altering degron motif	0.7503
p.P667A	LCLC-103H	lung	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation altering degron motif	0.7503
p.C233Y	SIDM00214	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.3056
p.C233Y	SNU-407	large intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.3056
p.D661Y	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.2778
p.D661Y	NCI-H838	lung	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.2778
p.S231N	SIDM01609	Endometrial Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.25
p.C668Y	ACH-000985	Colon/Colorectal Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation altering degron motif	0.7087
p.C668Y	LS-411N	large intestine	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation altering degron motif	0.7087
p.T678I	ACH-000999	Colon/Colorectal Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.0556
p.T678I	SNU-1040	large intestine	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.0556
p.D657V	ACH-001365	Lung Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1667
p.D657V	NCI-H847	lung	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.1667
p.T671I	ACH-001550	Skin Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.25
p.T671I	MCC13	skin	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.25
p.P286L	ACH-001738	Leukemia	CCLE	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.P286L	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.P670L	HuP-T4	pancreas	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.2778
p.A295S	HCC-15	lung	COSMIC	RRAPLPPMP	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6477
p.H224R	HT-144	skin	COSMIC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.0556
p.H224R	M059J	central nervous system	COSMIC	EKENK	DEG_APCC_KENBOX_2	234:238	Mutation rewiring degron network	0.0556
p.S971F	TOV-21G	ovary	COSMIC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1111
p.P988L	NCI-H2023	lung	COSMIC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1944
p.A1046T	CP66-MEL	skin	COSMIC	DKENN	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.K653R	SK-OV-3	ovary	COSMIC	LIIHSE	LIG_APCC_ABBA_1	663:668	Mutation rewiring degron network	0.0556
p.S983Y	LNCaP-Clone-FGC	prostate	COSMIC	PYSSS	DEG_SPOP_SBC_1	979:983	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COBLL1

UniProt ID: Q53SF7

Entrez ID: 22837

Protein name: Cordon-bleu protein-like 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COBLL1 in