DegronMD - Q569K4(ZNF385B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S234F	TCGA-D3-A8GM	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7982
p.D221Y	TCGA-DD-A4NV	LIHC	TCGA	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0556
p.S222Y	DO229031	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation substituting flanking lysine	0.1944
p.T245K	DO26949	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0556
p.P226H	DO26424	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation substituting flanking lysine	0.3056
p.G238W	DO47578	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.25
p.P224S	DO219480	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.G240E	DO42713	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1944
p.Q236L	ACH-000889	Myeloma	CCLE	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.3056
p.R240H	NCI-H64	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1944
p.N233S	H4	central nervous system	COSMIC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7069
p.V237A	RPMI-6666	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2778
p.S222L	MKN45	stomach	COSMIC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation substituting flanking lysine	0.1944
p.Q236R	PF-382	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons