DegronMD - Q5F1R6(DNAJC21)

DNAJC21

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V516I	TCGA-AP-A0LM	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.25
p.V516I	DO43306	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.25
p.V499A	TCGA-BS-A0TA	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0556
p.V499A	DO43298	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0556
p.T522A	DO234269	ESAD	ICGC	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0833
p.M523V	DO23226	LINC	ICGC	APSSS	DEG_SPOP_SBC_1	509:513	Mutation blocking phosphorylation signal	0.5
p.A507T	ACH-000998	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.2778
p.A507T	CW-2	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.2778
p.A520T	CW-2	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1389
p.T499N	HCC2998	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc