DegronMD - Q5H8C1(FREM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1880R	TCGA-17-Z055	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation altering degron motif	0.6457
p.L1892V	TCGA-44-8119	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0833
p.L1892V	DO24399	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0833
p.T1885I	TCGA-AP-A0LM	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.2778
p.T1885I	DO43306	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.2778
p.F1890L	TCGA-CA-6717	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1389
p.F1890L	DO8264	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1389
p.H1875Y	TCGA-E6-A1LX	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.2222
p.H1875Y	DO41020	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.2222
p.G1880E	TCGA-EE-A3AA	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation altering degron motif	0.6087
p.G1880E	DO222632	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation altering degron motif	0.6087
p.G1880E	DO37571	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation altering degron motif	0.6087
p.L1876M	TCGA-EO-A3AY	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.25
p.L1876M	DO43202	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.25
p.H1891Y	TCGA-FR-A8YC	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1111
p.H1891Y	DO222363	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1111
p.H1891Y	DO222843	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1111
p.H1891Y	DO50301	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1111
p.P1878L	TCGA-IH-A3EA	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.3056
p.P1878L	DO37667	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.3056
p.P1878T	DO46673	PACA	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.3056
p.S1887Y	DO232761	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.2222
p.P1878S	SIDM01187	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.3056
p.P1878S	ACH-000568	Breast Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.3056
p.P1878S	UACC-812	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.3056
p.S1884F	ACH-001982	Metastasis	CCLE	PGSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.3056

Kaplan plot for FREM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FREM1

UniProt ID: Q5H8C1

Entrez ID: 158326

Protein name: FRAS1-related extracellular matrix protein 1 (Protein QBRICK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FREM1 in